Sign Up for a Free Account
  • Updated 01.19.2021
  • Released 02.13.2002
  • Expires For CME 01.19.2024

Extracerebral fluid collections in infants



Extracerebral fluid collections in infants are common and of multiple etiologies. Most acute subdural hematomas occur non-accidentally. Infections can lead to subdural effusions and empyemas. Arachnoid cysts are the most common intracranial cysts. In otherwise normal infants with a large head, a common finding is benign enlargement of the subarachnoid space or subarachnomegaly, which has been called a variety of names in the literature, making interpretation of treatment and outcome data difficult.

Key points

• Extracerebral fluid collections are common in infants.

• Infants with benign enlargement of the subarachnoid space have large heads, often a family history of large heads, and imaging findings of frontal predominance of extraaxial fluid with no or mild ventriculomegaly.

• These infants have normal development other than sometimes minor delays that resolve; they have otherwise normal neurologic examinations and favorable outcomes.

• MRI can readily distinguish between subarachnoid and subdural fluid collections and is the study of choice.

• Preferred terms for this condition are “benign enlargement of the subarachnoid spaces of infancy” or “subarachnomegaly,” and other terms for this condition should be avoided.

Historical note and terminology

Intracranial fluid collections in infants were described initially by Galen and Oribasius in the 1850s. Dandy and Blackfan first introduced the term external hydrocephalus to describe infants with increased intracranial pressure and enlarged subarachnoid spaces (24). During the 20th century, it was recognized that bloody and clear fluid could arise from a number of causes other than hydrocephalus and that this fluid could accumulate in the subdural as well as subarachnoid spaces. Subdural hygromas were described (67), and chronic subdural hematoma was recognized as a frequent cause of head enlargement following trauma (40). Subdural effusions were reported to be a common complication of meningitis in infants (15; 60). Subdural hematomas and effusions were noted as complications of ventricular shunt procedures (07; 25). However, the distinction between the subarachnoid and subdural spaces was not always clearly determined; the literature is, therefore, often confusing regarding causes, treatment, and outcomes of these collections.

The more common extracerebral fluid collections encountered in infants include:

• dilated subarachnoid spaces (subarachnomegaly)/external hydrocephalus/multiple other names (see below)
• post-shunt subdural and subarachnoid effusions
• postinfectious subdural effusions
• subdural empyemas
• malignant subdural effusions
• chronic subdural hematoma
• subdural hygromas
• arachnoid and other extracerebral cysts

Start a MedLink Neurology trial
to unlock 3 free articles.

  • Nearly 3,000 illustrations, 
including video clips of 
neurologic disorders.

  • Every article is reviewed by our esteemed Editorial Board for accuracy and currency.

  • Full spectrum of 
neurology in 1,200 
comprehensive articles.

Questions or Comment?

MedLink, LLC

10393 San Diego Mission Rd, Suite 120

San Diego, CA 92108-2134

Toll Free (U.S. + Canada): 800-452-2400

US Number: +1-619-640-4660