Chordomas are histologically non-anaplastic tumors that are locally invasive, which usually present at the skull base, but can arise anywhere along the spinal axis and pelvis. MRI typically shows a locally invasive, enhancing mass within the bones of the clivus and skull base, sacrum, or vertebral bodies. They are thought to derive from notochordal remnants. Gross total resection is the initial approach to treatment and is correlated with improved overall survival; a small percentage of cases can progress to systemic metastases.
Nov. 23, 2021