General Neurology
Tibial nerve injuries
Jun. 04, 2022
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Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
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Primary stabbing headache consists of idiopathic transient and localized stabs of pain in the head. According to criteria from The International Classification of Headache Disorders, 3rd edition, the sharp stabbing pain is no longer restricted to the first division of the trigeminal nerve. Indomethacin is the main therapeutic option for this type of headache, but melatonin has been shown to be effective in some cases. Primary stabbing headache can occur in isolation, but it is frequently comorbid with another primary headache disorder, such as migraine. The differential diagnosis should include secondary etiologies for stabbing headaches.
• Primary stabbing headache is usually a benign self-limited primary headache disorder, consisting of sharp stabs of head pain. | |
• Age, gender, and whether the headache is comorbid with migraine influence the frequency of primary stabbing headache. | |
• Imaging is reasonable to exclude secondary causes. | |
• Indomethacin is the first-line treatment for primary stabbing headache. | |
• Other therapeutic options include melatonin, gabapentin, and celecoxib. |
Primary stabbing headache was first described in 1964, at which time it was called "ophthalmodynia periodica" (11). Since then, brief, sharp, jabbing pains that occur either as single episodes or in repeated flurries have been designated by various terms including: "icepick-like pains," "sharp short-lived head pains," "needle-in-the-eye syndrome," and "jabs and jolts syndrome" (23; 27; 14; 30; 18). The International Classification of Headache Disorders, 3rd edition, uses the term "primary stabbing headache," classified under item 4--other primary headaches.
• Most primary stabbing headache patients have very brief attacks (less than 3 seconds). | |
• Primary stabbing headache patients don’t have accompanying autonomic symptoms. | |
• The presentation of primary stabbing headache in children and adolescents varies widely and sometimes includes a family history. |
Primary stabbing headache is characterized by brief, sharp, severe jabbing pains about the head that occur either as single episodes or as brief repeated volleys. The International Classification of Headache Disorders (ICHD) has formulated criteria for this diagnosis (Table 1) under the term 4.7 “primary stabbing headache” (08). The pain resembles a stab from an icepick, nail, or needle and typically lasts from a fraction of a second to 1 to 2 seconds. Primary stabbing headache may have the shortest duration of all known headaches. The frequency of attacks varies immensely, ranging from 1 attack per year to 50 attacks per day. The pain was originally believed to be isolated to the distribution of the trigeminal nerve; however, studies have not supported this (13), and the most recent version of the ICHD has removed this location requirement for diagnosis. Icepick-like pains are more common in women and do occur in children (01).
(A) Head pain occurring spontaneously as a single stab or a series of stabs and fulfilling criteria B and C |
Most stabs last 3 seconds or less; rarely, stabs last for 10 to 120 seconds (06). These pains are usually unilateral, but may be bilateral. They occur mainly around the orbit or the temple and less frequently in the occipital and parietal areas. Attacks usually recur in the same area. If they occur in patients with other types of headache, they are characteristically located on the same side and frequently at the same site of the customary headache.
The attack frequency is generally low, with 1 or a few per day. Great variability exists in the temporal pattern of attacks. Most patients experience only single jabs, although some may have volleys of jabs. Attacks may be experienced as often as 50 times per day.
Accompanying phenomena, such as tearing, eye redness, or nausea, are absent.
A few patients, particularly those with comorbid migraine, have reported precipitating triggers for their idiopathic stabbing headaches. These triggers include rapid alterations in posture, physical exertion, bright light, and head motion during migraine attacks (16). In most patients, however, the pain is unprovoked.
Ammache and colleagues described a 27-year-old man with primary stabbing headache associated with monocular visual loss with scintillating scotoma ipsilateral to the pain (02). The patient had a history of migraine with aura.
Ahmed and colleagues reported on 42 children and adolescents with primary stabbing headache (01). Their mean age was 12 years. Most stabs were located in the extra-trigeminal regions. The frequency of the stabs ranged from daily to monthly. The presentation and nature of primary stabbing headache in children and adolescents varies widely. A family history of primary stabbing headache was identified in 2 patients in this cohort.
Primary stabbing headache is considered to be a benign condition, which may remit with time. In patients with infrequent attacks, education on the disorder may be sufficient, and medication may not be necessary. In patients on prophylactic treatments, periodic attempts to taper medication are reasonable to evaluate for possible remission.
It is hard to prognosticate about primary stabbing headache because of the great temporal variability. However, Kim and colleagues attempted to do so by prospectively screening and following patients diagnosed with primary stabbing headache in their clinic between June 2015 and March 2016 (09). They were able to identify 65 patients and found that most individuals followed 1 of 3 possible courses: a monophasic (n=31), intermittent (n=17), or chronic daily (n=12) pattern. Patients with a monophasic disease course tended to experience a duration of about 9 days, with attacks being of greater severity, occurring singly but with multiple attacks per day, side-locked attacks, and responding well to treatment. Patients with an intermittent pattern were more likely to be women and would experience symptoms on average for 2 years, with stabs being sporadic and of variable intensity. Chronic daily primary stabbing headache tended to last for 9 months, was more likely to occur in women, and presented with attacks that were longer-lasting and could change locations over the head. This study was the first to prospectively look at the clinical course of primary stabbing headache, and with the identification of 3 different typical patterns, hopefully future research will help clarify etiology and help optimize treatment strategies.
Patient 1. A 64-year-old man started having headaches 5 years prior. The pain was usually felt over the left temporal region. It lasted less than a second and was described as a sharp pain, stabbing in nature. Other areas were also affected by the stabs, including the left and right parietal regions and the right occipital region. He had 6 to 12 stabs a day. No accompanying symptoms were associated with the pain. Physical and neurologic examinations were normal. MRI and MRA of the brain were also normal. The patient was put on indomethacin 25 mg, 3 times a day, with significant improvement in the headache frequency; however, the medication was not well tolerated. Specific cyclooxygenase-2 inhibitors were then tried with good relief.
Patient 2. A 58-year-old woman started to complain of a sudden pain in right frontoparietal region for 3 weeks. The sudden stabs of pain, lasting about one minute, were very severe, always frightened the patient, and were followed by vocalization. She reported 2 to 3 episodes per day, without autonomic symptoms or any other manifestation in the beginning but the attacks were increased progressively. Indomethacin 25 mg 3 times per day was started, but she still had frequent attacks. Celecoxib 100 mg twice daily was prescribed, but it was not effective. The MRA of brain showed an aneurysm over right posterior communicating artery.
Stabbing headache may occur as a primary entity but is often also associated with another headache type and can occur secondary to other disorders.
Piovesan and colleagues reported stabbing headaches secondary to cerebrovascular disorders (20). Two women and 1 man, 76 years of age, 66 years of age, and 72 years of age, respectively, developed the headaches within 20 days after stroke. All patients responded to celecoxib, a cyclooxygenase-2 inhibitor.
The mechanism of primary stabbing headache is unknown. The potential mechanism includes irritation of trigeminal and extra-trigeminal nerves and intermittent impairment of central pain processing leading to hyperexcitability of neurons or spontaneous synchronous discharge of neurons. Ice pick pains may result from spontaneous discharges of trigeminal afferent fibers. Subpial grey matter and meningeal inflammation might sensitize trigeminal sensory fibers and lead to spontaneous activity of trigeminal branches (10). Further studies are necessary to determine the pathogenesis and pathophysiology of idiopathic stabbing headache.
• The reported prevalence of primary stabbing headache ranges from 0.2% to 35%. | |
• Primary stabbing headache is more common in women in the adult population and equal in children and adolescents. | |
• Primary stabbing headache is more common in migrainers. | |
• Primary stabbing headache may also occur in many other headache disorders, including tension-type headache, hemicrania continua, and cluster headache. |
The reported prevalence of primary stabbing headache ranges from 0.2% to 35% (16). The range may be due to different study settings and referral bias. In the adult population, primary stabbing headache occurs more commonly in women, with a female to male ratio of 1.49-6.6 to 1 (16). In children and adolescents, there is no gender predominance (07). The mean age of onset was around 28 years in a community-based study and 48 years old in a clinic-based study (32).
Sjaastad and colleagues studied the prevalence of idiopathic stabbing headache in the general population (the Vaga study) (28). In that study, conducted in Vaga, Norway, 1838 adults, 18 to 65 years of age, were examined. Jabs and jolts syndrome or idiopathic stabbing headache was diagnosed in 35.2% of the population. The female-to-male ratio was 1.49. They also studied extracephalic “jabs.” Three women had facial jabs, and 1 of them had pain spreading to the head. Four subjects had jabs occurring randomly throughout the body, including the cephalic area. Pure nuchal jabs were present in 12 subjects, 10 of whom were males. The characteristics of the extracephalic jabs were not different from the cephalic ones (29).
Primary stabbing pain occurs more commonly in individuals who have migraine (23; 19). Primary stabbing headache may also occur in many other headache disorders, including tension-type headache, hemicrania continua, and cluster headache, with a reported prevalence ranging from 21% to 84% in these other disorders (33; 07).
Trigeminal neuralgia involving the first division of the trigeminal nerve is a differential diagnostic possibility. The existence of trigger points, such as brushing teeth, eating, speaking, and the distribution of pain, occur mostly in maxillary and mandibular trigeminal nerve branches and are valuable distinguishing characteristics (ICHD-3).
Patients with SUNCT or SUNA (short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms) complain of unilateral headache with frequent (5 to 30 times per hour), short-lasting (15 to 60 seconds) attacks of pain in the V1 distribution (ICHD-3). The pain typically occurs in and around 1 eye and is accompanied by ipsilateral conjunctival injection, lacrimation, or other ipsilateral autonomic symptoms. The presence of accompanying autonomic changes is diagnostic.
Attacks of chronic paroxysmal hemicrania have pain characteristics and associated autonomic symptoms and signs similar to those of cluster headache, but the attacks of pain are short-lived (ICHD-3). These headaches can be distinguished from primary stabbing headache because the bouts of paroxysmal hemicrania generally last between 5 and 30 minutes and are associated with autonomic symptoms, such as ipsilateral lacrimation or rhinorrhea.
In primary cough headache, individuals can experience sudden severe headache, but the pain is generally holocephalic and is provoked by coughing or other Valsalva maneuvers (ICHD-3).
Another headache syndrome, nummular headache, has been described by Pareja and colleagues (17). It is a coin-shaped headache, usually located at the temporal area. Mild, continuous, but superimposed exacerbations lasting seconds may occur. Four of 13 patients reported stabbing pain.
A careful history and a normal examination are often sufficient to make the diagnosis. However, it is reasonable to do some neuroimaging, either an MRI or CT of the brain, as encephalitis, neoplasm (cerebral or pituitary), vasculitis (ie, giant cell arteritis), acute thalamic hematoma, cerebral aneurysms, and arteriovenous malformation can present as a stabbing headache (24; 31). Pituitary tumor, meningioma, and vestibular schwannomas were the most prevalent types of intracranial neoplasms for secondary stabbing headache (31). Valenca and colleagues identified that recent onset of stabbing headache, exclusively unilateral at the same location; crescendo pattern, triggered by head movements; or Valsalva maneuver were red flags for secondary stabbing headache (31). Recommendations for the diagnostic work up of headache with any phenotype, including isolated stabbing headache, should still presumably follow accepted recommendations to rule out secondary causes in the presence of red flags (24; 31).
Rampello and colleagues examined 26 patients with stabbing headache and found that 14 had an autoimmune disorder (22). Stabbing headache in patients with giant-cell arteritis has been reported (26). It is reasonable to check the erythrocyte sedimentation rate and C-reactive protein in patients older than 50 years of age presenting with new-onset stabbing headache. Unless there is other evidence of autoimmune disorder, it is low yield to extensively check the autoimmune survey.
• Primary stabbing headache is an indomethacin-responsive headache disorder. | |
• For patients with primary stabbing headache who cannot tolerate or do not respond to indomethacin, alternative treatments are gabapentin, melatonin, celecoxib, other COX-2 inhibitors, onabotulinumtoxin A (BoNTA), topiramate, acetazolamide, and nifedipine. |
Given the sudden onset and short duration of these attacks, acute treatment is not practical. When attempting to manage patients with frequent attacks of primary stabbing headache, a prophylactic medication needs to be used.
Primary stabbing headache is classified as an indomethacin-responsive headache disorder (16). The vast majority of patients tend to quickly respond to indomethacin 75 to 250mg/day, taken in divided doses, typically experiencing a response within a matter of days. Indomethacin has a few unique properties compared to other NSAIDs, including the inhibition of nitric oxide release (05), which may explain why some headache disorders including primary stabbing headache respond exquisitely to this specific NSAID. The adverse events of indomethacin include dyspepsia, gastrointestinal bleed, and renal toxicity.
In patients who cannot tolerate or do not respond to indomethacin, reasonable alternative treatments are gabapentin, melatonin, celecoxib, other COX-2 inhibitors, onabotulinumtoxin A (BoNTA), topiramate, acetazolamide, and nifedipine (25; 21; 16). Amitriptyline was used successfully in two pediatric patients with primary stabbing headache (15).
One systemic review of melatonin for primary headache (not specific for primary stabbing headache) included only 4 randomized controlled trials with poor methodological quality (351 participants) (12).The results showed that evidence is lacking for melatonin as first-line therapy, but it may be a treatment option in difficult headache cases or pediatric primary headaches in the short term (12). The structure of melatonin is similar to indomethacin, but its adverse events are fewer and include dizziness, nausea, and vomiting (03).
Indomethacin was effective in 65% to 74% patients who received it (18; 06).
There has been a case report from Colombia of a 7-year-old boy with primary stabbing headache (04). His attacks did not respond to coenzyme Q10 100 mg twice daily, but stopped after the initiation of melatonin 1.5 mg at bedtime (0.07 mg/kg). Improvement was seen within the first 2 weeks of starting melatonin. At the 6-month follow-up visit, there was sustained benefit and good adherence, with no adverse effects. The authors concluded that melatonin is a reasonable treatment for primary stabbing headache in the pediatric population.
Jong-Ling Fuh MD
Dr. Fuh of Taipei Veterans General Hospital and National Yang-Ming University School of Medicine has no relevant financial relationships to disclose.
See ProfileShuu-Jiun Wang MD
Dr. Wang of the Brain Research Center, National Yang-Ming University, and the Neurological Institute, Taipei Veterans General Hospital, has no relevant financial relationships to disclose.
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Toll Free (U.S. + Canada): 800-452-2400
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Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
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