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  • Updated 09.01.2020
  • Released 12.11.2000
  • Expires For CME 09.01.2023

Neuroimaging of headache



Although usually benign, headache can herald serious intracranial disease. Neuroimaging must be considered whenever secondary causes of headache are suspected. The authors discuss both the contribution that neuroimaging has made to our understanding of headache pathophysiology and the indications for neuroimaging in clinical practice. Common abnormalities on exam and their relationship to headache are explored, as well as the yield of neuroimaging in various clinical situations. Advances in imaging, such as functional MRI to study migraine pathophysiology, now demonstrate the role of the hypothalamus, brainstem structure, and network abnormalities. This review also highlights serious secondary causes of headache such as vascular disorders and tumors as a trigger for headache and, occasionally, cluster headache.

Key points

• Not all cases of headache require neuroimaging.

• When deciding whether or not to image a patient with headache, think about the “red flags.”

• Neuroimaging should be strongly considered in unusual primary headaches, such as the trigeminal autonomic cephalalgias, cough, or exertional headaches, etc.

Historical note and terminology

Headache diagnosis is clinical, based on a careful history and physical exam (49). The International Headache Society Classification defines headaches as primary, based on their clinical features or genetic markers, or secondary due to another proven cause (42). For primary headache disorders such as migraine, diagnosis does not rely on neuroimaging.

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ISSN: 2831-9125