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  • Updated 04.25.2021
  • Released 10.11.1993
  • Expires For CME 04.25.2024

Sleep, stroke, and vascular dementia



In this article, the author highlights the importance of obstructive sleep apnea as a risk factor for stroke and vascular dementia. Rehabilitation and recovery of stroke are less successful in the presence of sleep apnea. Habitual short and long sleep durations, long-standing night shift work, and periodic leg movements of sleep negatively affect cerebrovascular morbidity and mortality. Vascular dementia may be a complication of uncontrolled sleep apnea with hypoxemia.

Key points

• Obstructive sleep apnea is the most common sleep disorder and is a major risk factor for stroke and transient ischemic attack.

• Central sleep apnea is also a risk factor for ischemic stroke.

• Wake-up stroke may be related to severe sleep apnea, right-to-left shunt provoked by long-duration apnea events in patients with patent foramen ovale, or atrial fibrillation in sleep apnea patients.

• Vascular dementia may be a complication of uncontrolled sleep apnea with nocturnal hypoxemia.

Historical note and terminology

The major sleep disorder associated with stroke is sleep apnea (24). Gastaut described obstructive sleep apnea and pointed out its relevance for the pathogenesis of Pickwickian syndrome (31). The Pickwickian syndrome (now termed obesity hypoventilation syndrome) was recognized and named in 1956 (11). The association of sleep apnea with stroke was stressed with the discovery of snoring as a risk factor for stroke, the high incidence of sleep apnea in stroke patients (43), and a significant peak for stroke incidence in the morning hours (58). In 2008, the American Heart Association highlighted in a scientific statement concepts and evidence important to understanding the interactions between sleep apnea and vascular disease (84).

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