Muscle tissues contain the oxygen-binding protein, myoglobin. When striated muscles break down or rhabdomyolysis occurs, there is leakage of muscle cell content into the blood, leading to the excess amount to be excreted into the urine. This phenomenon is called myoglobinuria. The etiology of rhabdomyolysis is diverse and includes hereditary (metabolic diseases, dystrophinopathies, channelopathies) and acquired disorders (excessive muscular stress, ischemia, toxic damage, infections).
Jul. 22, 2021