Pyridoxine deficiency and toxicity
Both pyridoxine (vitamin B6) overdose and deficiency may cause peripheral neuropathy. Deficiency causes injury of motor and sensory axons whereas toxicity causes a pure sensory neuropathy or neuronopathy with sensory ataxia. Symptoms of deficiency include neuropathy, confusion, dermatitis, and insomnia; the neuronopathy caused by toxicity is characterized by poor coordination, numbness, and decreased sensation to touch, temperature, and vibration.
May. 15, 2021