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This 10-year-old boy has a 7-year history of multifocal motor and phonic tics. He exhibits stereotypic tics of his fingers and arms, associated with phonic tics. (Contributed by Dr. Joseph Jankovic.)
Childhood Degenerative & Metabolic Disorders
Feb. 22, 2020
Initial symptoms of progressive multifocal leukoencephalopathy include alterations in personality, changes in intellect, focal weakness, difficulty with motor skills, visual abnormalities, or sensory loss. It is an opportunistic demyelinating infection of the central nervous system that primarily affects immunosuppressed patients.
Aug. 31, 2020
Sep. 18, 2020
Epidermal nevus syndrome encompasses several sporadic congenital phenotypes characterized by epidermal nevi as the common denominator and associated
Nov. 14, 2016
Tick paralysis is a potentially fatal disease that causes rapidly ascending weakness, particularly in children. The typical presentation is with development of an unsteady, ataxic-type gait followed by an acute symmetric ascending flaccid paralysis. Clinical diagnosis is only secured by identifying an attached tick, with removal yielding rapid improvement.
Oct. 21, 2020
Tumefactive demyelinating lesions can present with motor, cognitive, cerebellar, and brainstem dysfunction, as well as headache, seizures, aphasia, cortical sensory loss, or psychosis. They are more likely to cause cortical signs, such as altered mental status and visual field deficits, than typical CNS demyelinating lesions. Two-thirds of patients with this condition subsequently develop multiple sclerosis.
Jan. 07, 2021
Common features of superficial siderosis include progressive sensorineural hearing loss, cerebellar ataxia, pyramidal signs, ataxia, and headache. It is caused by recurrent subarachnoid hemorrhage with accumulation of hemosiderin and other iron-containing pigments in the leptomeninges, brain surface, brainstem, cerebellum, cranial nerves, and spinal cord, and may be progressively disabling or fatal.
Sep. 27, 2020