Heat stroke is characterized by hyperpyrexia with core body temperature greater than 40°C (104°F) and neurologic dysfunction. Heat stroke is usually due to prolonged exposure to excessive atmospheric temperature but can also occur following prolonged exertion in athletes. It is distinct from fever due to disease. This article describes the pathophysiology, prevention, and management of heat stroke.
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• Neurologic manifestations such as seizures and impairment of consciousness are the most prominent features of heat stroke when core body temperature exceeds 41°C.
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• Apart from exposure to excessive heat, several diseases and drugs predispose to heat stroke.
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• Rapid cooling by various measures is the most important part of management if temperature goes above 40°C.
Historical note and terminology
Heat stroke, also termed "sun stroke," is characterized by hyperpyrexia with core body temperature greater than 40°C (104°F) and neurologic dysfunction. Heat stroke is the only condition that is a true heat illness as there is clear evidence for a pathological elevation of the core body temperature, and it is recommended that terms such as “heat fatigue”, “heat exhaustion,” and “heat syncope” should be removed from the modern lexicon (31). As an environmental hyperthermia, heat stroke is distinct from fever due to disease. Heat stroke is a total breakdown of thermoregulation, and 2 classical forms have been described: (1) nonexertional, which occurs during heat waves without physical exertion, and (2) exertional heat stroke, which typically follows strenuous sports.
Heat stroke has been mentioned in the older medical literature under one name or another. Most of the studies of thermoregulation were conducted following introduction into the clinical practice of thermometry in the 19th century. Historical perspectives on thermoregulation have been reviewed elsewhere (07).
A notable victim of this condition was Sir Victor Horsley, the British pioneer of neurologic surgery, who met an untimely death during World War I from heat stroke at the age of 59 years (37).