Neuropharmacology & Neurotherapeutics
Jul. 25, 2021
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Central pain syndrome is a neurological condition caused by damage to or dysfunction of the central nervous system (CNS). The CNS includes the brain, brainstem, and spinal cord. This syndrome can be caused by:
The pain associated with central pain syndrome differs widely among people partly because of the variety of potential causes. It may affect a large portion of the body or may be more restricted to specific areas, such as hands or feet. The extent of pain is usually related to the cause of the CNS injury or damage. Pain is typically constant, may be moderate to severe in intensity, and is often made worse by:
People have one or more types of pain sensations, the most major being burning. Along with the burning may be:
People may also have numbness in the areas affected by the pain. The burning and loss of touch sensations are usually most severe on the distant parts of the body, such as the feet or hands. Central pain syndrome often begins shortly after the injury or damage that caused it. It may also be delayed by months or even years, especially if it is related to post-stroke pain.
Pain medications often provide some—but not complete—relief. Tricyclic antidepressants such as nortriptyline or anticonvulsants such as neurontin (gabapentin) may be useful. Lowering stress levels also appears to reduce pain.
How can I or my loved one help improve care for people with central pain syndrome?
Consider participating in a clinical trial so clinicians and scientists can learn more about central pain syndrome and related disorders. Clinical research uses human volunteers to help researchers learn more about a disorder and perhaps find better ways to safely detect, treat, or prevent disease.
All types of volunteers are needed—those who are healthy or may have an illness or disease—of all different ages, sexes, races, and ethnicities to ensure that study results apply to as many people as possible, and that treatments will be safe and effective for everyone who will use them.
For information about participating in clinical research visit NIH Clinical Research Trials and You. Learn about clinical trials currently looking for people with central pain syndrome at Clinicaltrials.gov.
Where can I find more information about central pain syndrome?
The following organization may help individuals, families, friends, and caregivers of people living with central pain syndrome:
American Chronic Pain Association (ACPA)
Phone: 916-632-0922 or 800-533-3231
Content source: https://www.ninds.nih.gov/health-information/disorders/central-pain-syndrome Accessed June 22, 2023.
The information in this document is for general educational purposes only. It is not intended to substitute for personalized professional advice. Although the information was obtained from sources believed to be reliable, MedLink, its representatives, and the providers of the information do not guarantee its accuracy and disclaim responsibility for adverse consequences resulting from its use. For further information, consult a physician and the organization referred to herein.