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San Diego, CA 92108-2134
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Gait is impaired by severe scissoring due to spasticity of the adductor muscles. (Courtesy of Dr. Sid Gilman.)
May. 26, 2021
Behavioral & Cognitive Disorders
Autism spectrum disorder is characterized by impairment in social communication, repetitive behaviors, restricted interests, and hyper- or hyposensitivity to sensory stimuli. Lack of eye contact or facial expressions, and lack of interest in others, are also features. It is a neurodevelopmental condition typically diagnosed in childhood.
Sep. 29, 2020
Stroke & Vascular Disorders
The goal of stroke therapy is to reestablish blood flow to viable brain tissue to reduce the degree of injury. Dissolution of the thrombus is mediated by localized fibrinolysis and degradation of fibrin by plasmin. Treatment is time-sensitive following stroke, and thrombolytic drugs can be used within the first 3 hours.
Jan. 07, 2021
Neuropharmacology & Neurotherapeutics
Sep. 05, 2021
Cytomegalovirus is the most common cause of polyradiculopathy in AIDS. It occurs in about 2% of HIV-infected patients referred to neurologists. Expeditious
Feb. 25, 2021
Although arsenic is more commonly known for intentional poisonings in homicides or suicides, the most common etiology of arsenic toxicity worldwide is ingestion of contaminated drinking water in endemic areas. The neuropathy related to arsenic is rarely seen without other systemic manifestations, including abdominal pain and skin changes. Arsenic neuropathy causes painful paresthesias and, with higher level or continued exposure, length-dependent weakness.
Jun. 17, 2021
Neuromyelitis optica spectrum disorder (NMOSD) is a destructive, inflammatory disease of the CNS historically characterized by selective involvement of the spinal cord and optic nerves. Manifestations of NMOSD include optic neuritis, transverse myelitis, and simultaneous optic nerve and spinal cord involvement. A prodrome of headache, low-grade fever, myalgia, fatigue, upper respiratory symptoms, or gastrointestinal symptoms can precede neurologic deficits.
Feb. 23, 2021
Congenital muscle fiber-type disproportion is a condition that can be defined only in the muscle biopsy by 2 obligatory criteria of "disproportion":
Jun. 21, 2021