Infectious Disorders
Acute flaccid myelitis
Aug. 26, 2024
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Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
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This T2-weighted brain MRI from a 37-year-old man with cerebrotendinous xanthomatosis shows signal change within the cerebellar hemispheres associated with significant volume loss. There was a combination of low signal change suspected to be due to calcification and raised signal change in the rest of the cerebellar hemispheres extending into the cerebellar peduncles bilaterally. Clinical presentation: The patient had a history of learning difficulties, requiring special classes at school. He was evaluated for worsened speech and marked disequilibrium and required assistance to walk. Examination showed no cataracts or xanthomas. Neurologic examination showed marked dysarthria, limb and gait ataxia, diffusely increased tone, and pathologically brisk reflexes in both legs with bilateral extensor plantar responses. (Source: Islam M, Hoggard N, Hadjivassiliou M. Cerebrotendinous xanthomatosis: diversity of presentation and refining treatment with chenodeoxycholic acid. Cerebellum Ataxias 2021;8[1]:5. Creative Commons Attribution 4.0 International License.)