Sign Up for a Free Account

This is an image preview.
Start a Free Account
to view the full image.

Sign Up for a Free Account For information on discounts, see Plans & Pricing

  • Nearly 3,000 illustrations, including video clips of neurologic disorders.

  • Every article is reviewed by our esteemed Editorial Board for accuracy and currency.

  • Full spectrum of neurology in 1,200 comprehensive articles.

  • Listen to MedLink on the go with Audio versions of each article.

Schematic diagram of oxidative decarboxylation

For pyruvate dehydrogenase (R=H). For alpha-ketoglurate (R=CH2-COO-). Step A is the E1k-mediated decarboxylation step, utilizing TPP as a cofactor. Steps B and C are E2k-mediated sequential succinylation steps, ultimately forming succinyl CoA and utilizing lipoamide and coenzyme A as cofactors. Steps D and E are E3-mediated electron transfer reactions that utilize FAD and NAD as cofactors. (Courtesy of Wikimedia Commons. Public domain.)

Related Media

Associated Disorders

  • DOOR syndrome
  • Dihydrolipoyl dehydrogenase deficiency
  • Eronen syndrome
  • Ketoacidotic crisis
  • Lactic acidosis
  • Maple syrup urine disease