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Anaplastic oligodendroglioma, IDH-mutant and 1p/19q codeleted (microscopy)

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(A) H & E (400X). (B) Nuclear atypia and increased mitotic activity (circled). (C) Prominent microvascular proliferation. (D) Region of focal necrosis with palisading tumor cells. (E) Positive immunohistochemical stain for mutant IDH1-R132H protein. (F) Retained nuclear ATRX expression. (Contributed by: Dr. Mark Curtis.)