Piloid cells in pilocytic zone (photomicrograph)

Balo concentric sclerosis

Balo concentric sclerosis is a CNS disease with characteristic pathological and MRI features consisting of alternating concentric rings of demyelinated and relatively myelinated tissues. It shares features with other forms of acute demyelination, including multiple sclerosis. Patients with Balo concentric sclerosis often present with progressive encephalopathy, fever, behavioral changes, cognitive deficits, headache, seizures, increased intracranial pressure, and focal neurologic deficits that most commonly are localized to the supratentorial compartment.