Hippocampus from patient with Alzheimer disease (photomicrograph)

Motor and multifocal motor neuropathies

Motor and multifocal motor neuropathy is characterized by weakness with muscle wasting and fasciculations, and may resemble motor neuron disease. Sensory symptoms are notably absent, with only the occasional complaint of paresthesias. Motor weakness typically occurs in the distribution of individual motor nerves rather than the segmental distribution seen in amyotrophic lateral sclerosis. Compared with amyotrophic lateral sclerosis, motor neuropathies have a favorable prognosis and a prolonged course.