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Hippocampus from patient with Alzheimer disease (photomicrograph)

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Section of hippocampus stained with anti-tau-2 antibody. Only intracellular tangles (flame-shaped structures surrounding the clear nucleus) are demonstrated. Also notice clusters of brown reactive product (two left, two in the center, and one top left) representing neuritic plaques. (ABC method, 1:15,000; x62.5; Sigma, St. Louis, MO) (Contributed by Dr. David Geldmacher.)