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Trophozoite forms of Balamuthia mandrillaris in cerebral cortex (photomicrograph)

Trophozoite forms of Balamuthia mandrillaris in cerebral cortex appear as large cells (15 to 40 µm) with vesicular nucleus, prominent nucleolus, and granular eosinophilic cytoplasm. (Courtesy of Dr. David A. Griesemer, Medical University of South Carolina.)