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Abbreviations: F: factor; t-PA: Tissue plasminogen activator; Ca: Calcium; PAI-1: plasminogen activator inhibior-1. (Contributed by Dr. Anjali Sharathkumar.)
Sep. 30, 2020
Nov. 24, 2020
Neuropharmacology & Neurotherapeutics
Mar. 07, 2021
Sep. 05, 2020
Acute necrotizing hemorrhagic leukoencephalitis is a disorder that often follows a virus or mycoplasma infection and evolves rapidly to coma and death. Lesions are hemorrhagic, with fibrinoid necrosis and polymorphonuclear neutrophil infiltration that is associated with demyelination. The devastating immune response may be from excess sensitization to 1 or more unknown antigens. COVID-19 infection induces acute necrotizing hemorrhagic leukoencephalitis.
Mar. 26, 2021
Childhood Degenerative & Metabolic Disorders
Gaucher disease is a storage disorder caused by mutations in the GBA1 gene. Neuronopathic Gaucher disease has a very wide clinical spectrum--from congenital and early infantile Gaucher disease type 2 to very mild with horizontal supranuclear gaze palsy as the only neurologic abnormality and normal or even superior intelligence. GBA1 mutations are a risk factor for developing neurodegenerative diseases.
Dec. 28, 2019
Epilepsy & Seizures
The following are 5 criteria for the diagnosis of self-limited epilepsy with centrotemporal spikes (SLECTS): (1) onset between the ages of 2 and 13 years; (2) absence of neurologic or intellectual deficit before the onset; (3) partial seizures with motor signs, frequently associated with somatosensory symptoms or precipitated by sleep; (4) a spike focus located in the centrotemporal (rolandic) area with normal background activity on the interictal EEG; and (5) spontaneous remission during adolescence.
Nov. 11, 2020
Multiple sclerosis (MS) lesions in the brain and spinal cord damage every function of the central nervous system. Clinical symptoms vary from mild to aggressive; the course can be relapsing-remitting or progressive, and the symptoms and course evolve over time. Protean symptoms include fatigue and disturbed sensory, motor, bladder, bowel, sexual, cerebellar, brainstem, optic nerve, and cognitive realms.
Sep. 26, 2017