General Neurology
High-pressure neurologic syndrome
Dec. 01, 2025
This is an image preview.
Start a Free Account
to view the full image.
-
Nearly 3,000 illustrations, including video clips of neurologic disorders.
-
Every article is reviewed by our esteemed Editorial Board for accuracy and currency.
-
Full spectrum of neurology in 1,200 comprehensive articles.
-
Listen to MedLink on the go with Audio versions of each article.
Cellular creatine homeostasis
Rates of CT synthesis and uptake determine tissue-specific CT content. The rate-limiting step in CT synthesis, arginine:glycine amidinotransferase (AGAT), is controlled by product inhibition (1), and CT negative feedback loop (2). Abbreviations: GAA, guanidinoacetate; GAMT, guanidinoacetate methyltransferase; SAH, S-adenosyl homocysteine; SAM, S-adenosyl methionine; SLC6A8 , CT transporter. (From: Tkachyova I, Tropak MB, Lee A, Datti A, Ito S, Schulze A. Targeting AGAT gene expression - a drug screening approach for the treatment of GAMT deficiency. Expert Opin Drug Discov 2024;19(11):1383-97.)