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EEGs before and 8 weeks after treatment of a patient with GAMT-D

Electroencephalograms (common reference leads) before (upper record) and 8 weeks after (lower record) treatment of a patient with GAMT deficiency. The first record shows a continuous generalized slow spike-wave activity of high amplitudes, and the second one shows diffuse theta-delta slowing without focal accentuation and without epileptic discharges. (From: Schulze A, Ebinger F, Rating D, Mayatepek E. Improving treatment of guanidinoacetate methyltransferase deficiency: reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation. Mol Genet Metab 2001;74[4]:413-9.)

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