Adenylosuccinate lyase deficiency
Jun. 19, 2022
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Basal views of brain of 2 neonates at autopsy, after 2 weeks of formalin fixation. The one on the left (NA90/84) has global cerebellar hypoplasia. The one on the right (A36/84) is a normal, age-matched control. The brainstems and cerebral hemispheres appear externally normal in both. There is a thin layer of subarachnoid blood in the leptomeninges of A36/84, giving it a darker appearance; this is, though, unrelated to the cerebellar hypoplasia. Note the difference in the lateral extension of the cerebellar hemispheres in the two brains. (Contributed by Dr. Harvey Sarnat.)