Neuropathies associated with monoclonal gammopathies
Monoclonal gammopathy (IgG, IgM, or IgA) is identified in 10% of patients with idiopathic neuropathy. Approximately half of these associations are coincidental given the prevalence of monoclonal gammopathies in the general population. Peripheral neuropathy and monoclonal gammopathy may be the presenting features of a plasma cell dyscrasia (preneoplastic disorders). Patients with nonmalignant monoclonal gammopathy should be followed carefully; malignant transformation occurs at a rate of 1.5% per year.
Nov. 05, 2020