3525 Del Mar Heights Rd, Ste 304San Diego, CA 92130-2122
Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Neuropharmacology & Neurotherapeutics
Sep. 05, 2021
Epilepsy & Seizures
Generalized onset tonic seizures are epileptic seizures of mainly severe epilepsies of neonates, infants, and children with learning difficulties who also suffer from frequent seizures of other types. They manifest with abrupt onset and termination of sustained increase in muscle contraction, usually lasting a few seconds to 1 minute. Lennox-Gastaut syndrome is the prototype disorder of generalized onset tonic seizures.
Apr. 26, 2021
Childhood Degenerative & Metabolic Disorders
Batten disease, or neuronal ceroid lipofuscinoses, are common neurodegenerative diseases of childhood. All forms of Batten disease are inherited. There are currently 14 different genes and over 360 mutations that underlie these devastating brain disorders. Typical clinical findings include retinopathy leading to blindness, sleep problems, motor abnormalities, myoclonic seizures, dementia, and premature death. Definitive diagnosis relies on enzymatic assays or DNA testing.
Jan. 19, 2020
Aug. 13, 2021
Sleep terrors are sudden, partial awakenings from deep non-REM sleep, associated with intense motor behavior and strong autonomic responses. Sleep terrors are mainly a childhood phenomenon, with peak prevalence at 5 to 7 years of age. They are usually benign with a tendency for spontaneous resolution. Safety measures are of primary importance to protect the patient from injury, but treatment with medications is not usually necessary.
Mar. 04, 2021
Frontal lobe seizures are typically brief, nocturnal, and without loss of consciousness, and can have unusual manifestations such as hyperactive behavior. Seizure types include focal clonic seizures, asymmetric tonic seizures, hyperkinetic seizures, absence type seizures, and masticatory seizures.
Aug. 28, 2020
Motor and multifocal motor neuropathy is characterized by weakness with muscle wasting and fasciculations, and may resemble motor neuron disease. Sensory symptoms are notably absent, with only the occasional complaint of paresthesias. Motor weakness typically occurs in the distribution of individual motor nerves rather than the segmental distribution seen in amyotrophic lateral sclerosis. Compared with amyotrophic lateral sclerosis, motor neuropathies have a favorable prognosis and a prolonged course.
Oct. 18, 2021
Myoclonus epilepsy with ragged-red fibers (MERRF) is a multisystem mitochondrial disorder defined by myoclonus, generalized epilepsy, ataxia, and myopathy with ragged-red fibers detected in muscle biopsy. MERRF patients often have sensorineural hearing loss, cognitive impairment, multiple lipomatosis, peripheral neuropathy, exercise intolerance, ptosis, ophthalmoparesis, optic atrophy, cardiomyopathy, muscle wasting, respiratory impairment, diabetes, muscle pain, tremor, and migraine.
Jun. 10, 2021