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FDA-approved disease-modifying therapies for multiple sclerosis

Since 1993, 20 disease-modifying therapies have been approved by the FDA for the treatment of relapsing multiple sclerosis. Ocrelizumab remains the only therapy approved for primary progressive multiple sclerosis. Ublituximab is the newest therapy and has been available since mid-2023 for the treatment of relapsing multiple sclerosis. Four Bruton tyrosine kinase (BTK) inhibitors are in phase III clinical trials, including for relapsing and progressive indications. (Contributed by Dr. Andrew Wolf.)