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T2-weighted sagittal image shows a low T2-signal intramedullary mass at cervical cord. Note multiple serpiginous flow-voids on the back of the spinal cord. (Contributed by Dr. Gaurang Shah.)
Neuropharmacology & Neurotherapeutics
Sep. 10, 2020
Clinically isolated syndrome is a first symptomatic episode of central nervous system dysfunction due to inflammatory demyelination, which may indicate the onset of multiple sclerosis, or may be an isolated incident. Patients may show accelerated brain atrophy and mild cognitive impairments.
Sep. 30, 2020
Traditionally, vaccines have been developed for prevention of infectious diseases. For example, vaccines are the most important and effective preventive measures against COVID-19 and its neurological manifestation, ie, neuroCOVID. Apart from prevention of infectious diseases, vaccines are in development for therapeutic use in noninfectious diseases. Indications for therapeutic vaccines include neurodegenerative disorders, traumatic brain injury, glioblastoma, and multiple sclerosis.
Apr. 03, 2021
Childhood Degenerative & Metabolic Disorders
Dec. 28, 2020
Triptans, selective serotonin receptor (5-HT) agonists, are used in the treatment of acute migraine attacks as well as nonmigraine headaches. Their effect is related to their multiple mechanisms of action at sites implicated in the pathophysiology of migraine, eg, vasoconstriction.
Nov. 14, 2020
Brain metastases are neoplasms that originate in tissues or organs outside the brain and spread to involve the brain parenchyma. Metastasis to the brain parenchyma is the single most frequent neurologic complication of several common neoplasms, including lung cancer, breast cancer, and melanoma. Brain metastases often have a devastating impact on patients' quality of life and are fatal if not controlled.
Aug. 26, 2019
Behavioral & Cognitive Disorders
Foix-Chavany-Marie syndrome is a rare cortical form of supranuclear (pseudobulbar) palsy caused by bilateral anterior opercular lesions; in this syndrome there is an “automatic-voluntary dissociation” of motor function of lower cranial nerves. Manifestations include volitional paralysis of masticatory, facial, pharyngeal, and lingual muscles innervated by cranial nerves V, VII, IX, X, and XII, with preserved autonomic and emotional innervation of these muscles. There are 5 predominant clinical groups of Foix-Chavany-Marie syndrome.
Oct. 21, 2020
Jul. 26, 2021