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Diagnostic algorithm for auldt-type diffuse gliomas

In WHO CNS-5, all IDH-mutant infiltrating astrocytomas are considered a single entity (ie, astrocytoma, IDH-mutant) and are graded as CNS WHO Grade 2, 3, or 4 depending on both histologic and molecular features. (Reproduced from: Weller M, van den Bent M, Preusser M, et al. EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. Nat Rev Clin Oncol 2021;18(3):170-86.)