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Nerve biopsy in lepromatous leprosy: hematoxylin and eosin stain

Longitudinal section of peripheral nerve showing absence of lymphocytic infiltration. There is splitting of perineurium in layers by sheet of foamy cells and edema. (625X) (Contributed by Ravindra Kumar Garg.)

Associated Disorders

  • Antineutrophil cytoplasmic autoantibodies in serum
  • Arthritis
  • Asymptomatic hepatic infiltration
  • Blood: hemolytic anemia, megaloblastic anemia
  • Bone: osteomyelitis, osteoporosis, osteoperiostitis
  • Dapsone hypersensitivity syndrome
  • Dapsone-related motor neuropathy
  • Eyes: uveitis, iritis, iridocyclitis, corneal ulcers, blindness
  • Generalized lymphadenopathy
  • Gynecomastia
  • High serum antiphospholipid antibodies
  • Kidney: nephrotic syndrome, renal amyloidosis, glomerulonephritis
  • Larynx: fibrosis of vocal cords, laryngeal ulcer, hoarseness of voice
  • Neuropathic osteoarthropathy
  • Nose: rhinitis, crusting, epistaxis, anosmia, nasal collapse
  • Palatal perforation
  • Plantar ulcer
  • Testes: acute orchitis, testicular atrophy, azoospermia, hypogonadism
  • Thalidomide neuropathy
  • Ulnar neuritis
  • Vitiligo