Craniopharyngioma is a rare histologically low-grade (WHO grade 1) suprasellar tumor believed to originate from Rathke’s pouch. Due to its suprasellar location, patients with craniopharyngioma often present with visual and endocrine symptoms. There are 2 craniopharyngioma subtypes: adamantinomatous and papillary. Adamantinomatous craniopharyngiomas have an activating mutation in the gene encoding β-catenin whereas papillary craniopharyngiomas carry the BRAF V600E mutation.
Jul. 21, 2021