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Lumbosacral agenesis (photomicrograph showing primary amyoplasia of lower leg of an infant)

Part of the tibia is seen at the left. The muscle is almost entirely replaced by fat and connective tissue in the region of the soleus, with only a narrow band of myofibers surrounded by fat. Autopsy specimen of a term infant of a diabetic mother. (Hematoxylin-eosin; x40) (Contributed by Dr. Harvey B Sarnat.)

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Associated Disorders

  • Anorectal malformations
  • Anterior meningocele
  • Hirschsprung disease
  • Maternal diabetes mellitus
  • Meningomyelocele
  • Recto-meningeal fistula
  • Sacral teratoma