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Sural nerve biopsy (electron microscopy)

There is a reduced density of myelinated fibers with relative preservation of unmyelinated fibers. Inflammatory cells are not seen. Bar = 5 microns. (Contributed by Dr. Hugh Willison.)

Associated Disorders

  • Anti-disialosyl or anti-B series ganglioside antibodies
  • CANOMAD (chronic ataxic neuropathy with ophthalmoplegia, M-protein, agglutination and disialosyl antibodies)
  • Cold agglutinin disease
  • IgM paraproteinemia
  • Peripheral neuropathy with anti-GD1
  • Sensory ataxic neuropathy
  • Sensory neuropathy