Neuro Podcases: Genetic Causes of ALS/FTD with Prof. Isaacs

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Listen here to Neuro Podcases, A Clinical Neuroscience Podcast, a free online educational resource to help you learn clinical neuroscience. Created by clinical Neurologists, each episode involves a conversation with an expert discussant centered around an important clinical topic.

The ‘Essentials’ podcast series has been created for those encountering clinical neuroscience for the first time, the ‘Advanced’ episodes will appeal to those wanting to study topics in greater detail. Visit www.neuropodcases.co.uk for further information. The Neuro Podcases Team can be reached by email at contact@neuropodcases.co.uk.

Originally released: February 26, 2025

In this episode of our Neuroscience Research series, hosts Filippo Dall'Armellina and Michael Cearns welcome Professor Adrian Isaacs (UCL), who investigates the molecular and cellular mechanisms underlying FTD and ALS.

Research Highlights:

- Paper 1: Mizielinska S, et al. C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins. Science, 2014. PMID 25103406

- Paper 2: Kempthorne L, et al. Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo. Nat Commun., 2025. PMID 39779704

- Paper 3: Giblin A, et al. Neuronal polyunsaturated fatty acids are protective in ALS/FTD. Nat Neurosci., 2025. PMID 40000803

We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode’s original release date.