General Neurology
Renal failure: neurologic complications
Jan. 25, 2024
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07.31.2023
Research Highlights:
A novel vaccine that targets inflamed brain cells associated with Alzheimer disease may hold the key to potentially preventing or modifying the course of the disease, according to preliminary research presented at the American Heart Association’s Basic Cardiovascular Sciences Scientific Sessions 2023. The meeting is in Boston, July 31 to August 3, 2023, and offers the latest research on innovations and discovery in cardiovascular science.
Previously, researchers at Juntendo University Graduate School of Medicine in Tokyo, Japan developed a vaccine to eliminate senescent cells expressing senescence-associated glycoprotein (SAGP) - a senolytic vaccine that improved various age-related diseases including atherosclerosis and Type 2 diabetes in mice. Another study also found that SAGPs are highly expressed in glial cells in people with Alzheimer disease. Based on the findings from these studies, the researchers tested this vaccine in mice to target SAGP-overexpressed cells to treat Alzheimer disease.
“Alzheimer’s disease now accounts for 50% to 70% of dementia patients worldwide. Our study’s novel vaccine test in mice points to a potential way to prevent or modify the disease. The future challenge will be to achieve similar results in humans,” said lead study author Chieh-Lun Hsiao, Ph.D., a post-doctoral fellow in the department of cardiovascular biology and medicine at Juntendo University Graduate School of Medicine in Tokyo. “If the vaccine could prove to be successful in humans, it would be a big step forward towards delaying disease progression or even prevention of this disease.”
In this study, the research team created an Alzheimer disease mouse model that mimics a human brain and simulates amyloid-beta-induced Alzheimer disease pathology. To test the efficacy of the SAGP vaccine, the mice were treated with a control vaccine or the SAGP vaccine at two and four months old. Usually, people in the late stage of Alzheimer disease lack anxiety, which means they are not aware of the things around them. The mice who received the vaccine had anxiety, which means that they were more cautious and more aware of things around them – a sign researcher say could indicate a lessening of the disease. In addition, several inflammatory biomarkers of Alzheimer disease were also reduced.
The study found:
In Alzheimer disease, an accumulation of brain proteins called amyloid beta peptides clump together forming plaques that collect between neurons and disrupt cell function, according to the National Institute on Aging, a division of the National Institutes of Health. Vascular problems may also lead to a breakdown of the blood-brain barrier, which usually protects the brain from harmful agents while allowing access for glucose and other necessary factors. This faulty blood-brain barrier prevents glucose from reaching the brain and prevents the clearing away of toxic beta-amyloid and proteins, which results in chronic inflammation and Alzheimer disease progression.
“Earlier studies using different vaccines to treat Alzheimer disease in mouse models have been successful in reducing amyloid plaque deposits and inflammatory factors, however, what makes our study different is that our SAGP vaccine also altered the behavior of these mice for the better,” Hsiao said.
According to the researchers, previous research suggests that the SAGP protein is highly elevated in microglia, which means that microglia are very important cells to target in Alzheimer disease. Hsiao said, “By removing microglia that are in the activation state, the inflammation in the brain may also be controlled. A vaccine could target activated microglia and remove these toxic cells, ultimately repairing the deficits in behavior suffered in Alzheimer’s disease.”
According to the 2023 American Heart Association Statistical Update, about 3.7 million Americans, ages 30 years and older, had Alzheimer disease in 2017, and this number is projected to increase to 9.3 million by 2060.
Source: News Release
American Heart Association
July 30, 2023
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