Morvan syndrome and related disorders associated with CASPR2 antibodies
Jan. 23, 2023
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Apraxia refers to the selective inability to produce skilled movements following brain damage, without affecting unskilled movements. Apraxia can be observed in diverse diseases, including stroke, brain tumors, head injury, schizophrenia, corticobasal syndrome, Alzheimer disease, progressive supranuclear palsy, and other degenerative illnesses. When it has been associated with focal brain injury, apraxia has usually been associated with left parietal pathology. The clinical value of apraxia is not well scientifically supported, particularly for whether the diagnosis of apraxia can recommend rehabilitation. However, diagnosing apraxia can assist determining whether a dementing illness is Alzheimer disease versus frontotemporal dementia.
• Apraxia is the selective impairment in producing learned (or skilled) movements that does not affect unlearned, basic movements.
• Following focal structural hemispheric injury, apraxia is most often associated with left parietal pathology.
• Three major subtypes of apraxia are frequently distinguished: (1) limb kinetic apraxia, (2) ideokinetic or ideomotor, and (3) ideational apraxia.
• Treating apraxia is controversial. If it should be pursued, it should focus on compensating for the disorder and managing the environment of the apraxic patient, rather than treating apraxia directly, owing to the lack of a standard of treatment.
Apraxia is defined as the loss of the ability to produce purposeful, skilled movements as the result of brain damage (85; 57). Liepmann defined apraxia as impairment in the production of learned (or skilled) movements not caused by weakness, paralysis, incoordination, or sensory loss (77). Apraxia is manifested in a person's inability to "move the moveable parts of the body in a purposeful manner even though motility is preserved" (73). The term apraxia most often pertains to a single action (eg, operating a screwdriver, sewing with a needle, hitchhiking, kicking a ball, sucking on a straw) as opposed to series of movements (eg, putting together a meal, changing a tire). In some instances, examiners evaluate simple actions that require 2 or more limbs (eg, playing a guitar, boxing, operating a steering wheel, putting on eyeglasses, riding a bicycle).
This article will focus on apraxia as generally defined as failure to carry out skilled (for the most part culturally learned) movements. This article will not discuss disorders of basic, universal, unskilled movements such as ordinary walking, breathing, eye opening, reaching, self-scratching, etc. Therefore, this review will not address gait apraxia, eye opening apraxia, or respiratory inhibitory apraxia, terms that appear in clinical literature. In addition, other disorders that are termed “apraxia” will be excluded because they do not reflect disturbances of predominantly movement execution. Thus, constructional apraxia (eg, disrupted planning of drawing) appears to be more of a conceptual and visuoperceptual disorder than a skilled motor disorder; dressing apraxia with regard to putting on garments by inserting one’s own limbs and trunk appears to be more closely related to a spatial planning disorder or neglect; and apraxia of speech is a specific impairment in talking (inconsistency with producing speech sounds or its rhythm).
In 1861 Jackson drew attention to the dissociation between performing an action upon command versus acting spontaneously in brain illness patients, in particular, tongue protrusion (Pearce 2009). This dissociation later became termed “automatic-voluntary dissociation”, which is detailed in a separate MedLink Neurology article; Jackson himself did not use the term “apraxia.” In the late 1800s Steinthal was the first to use “apraxia” to describe a disturbance in skilled limb movements following brain damage. Steinthal wrote that apraxia consisted of a disturbance in the relationship between movements and the objects on which the movements were enacted, ie, when playing a violin (124).
Liepmann in turn used “apraxia” to mean a general incorrect use of objects, based on his landmark clinical account of a civil servant who, among his other cognitive deficits, used his right hand—but not his left—inappropriately for objects that were presented to him (73). Today the unusual movements would better be termed “alien hand” (more specifically, the callosal alien hand variant), because intermanual conflict also appeared in this man. Liepmann’s consequent avid examining other patients for either abnormal object use or defective pantomiming use of such objects inspired a surge of other case reports of apraxia, primarily in the German neurologic literature, but also in the French and English literature. This fruitful period of the first 2 decades of the 20th century founded an almost continuous publication on this disorder to the present. In his 1900 report, Liepmann noted that other published instances of apraxia had preceded his but had not used the term “apraxia.”
Subsequently, there was a lack of consensus concerning the mechanism for and defining apraxia. For example, other researchers had observed the disturbances of object related movements in aphasic patients but attributed both deficits to asymbolia, a generalized disturbance in the comprehension or production of symbols in any modality, including language and gesture (27; 35). Goldstein also related disorders of action to the patient's aphasia and included skilled movement problems within a definition of aphasia (49). Pick, however, defined apraxia as an asymbolia that was not included within a definition of aphasia (98). Another mechanism proposed to explain apraxia was posited by Kussmaul, who defined apraxia as an agnosia, an impairment in the recognition of tools, which then affects the movements produced with tools (55). In 1905, Liepmann described a patient who presented with a severe inability to produce volitional movements with the left hand as well as profound aphasia. Liepmann's point in describing this case was that a disorder of language or gnosis (knowledge) could not explain apraxia of only 1 hand. Movement failures created by language or gnosis deficits would affect both hands. This would later be considered an early description of callosal apraxia (45). Thus, Liepmann was the first to describe the mechanism of apraxia as a disorder of movement planning (74; 75; 76; 77; 73).
Liepmann (75) studied 89 brain-damaged patients, 42 with left hemiplegia (thus, suspected to have right hemisphere lesions), 41 with right hemiplegia (thus, suspected to have left hemisphere lesions), 5 nonhemiplegic with aphasia (left hemisphere lesions), and 1 who was neither hemiparetic nor aphasic but was apraxic. The patients were asked to produce 3 types of movements: (1) expressive movements such as waving and saluting; (2) transitive (tool-based) and intransitive (non-tool-based) movements to command from memory, such as playing an organ grinder and snapping the fingers; and (3) manipulations of actual tools such as combing hair with a comb and writing with a pen. Liepmann found that the patients with right hemisphere damage rarely made errors on these tasks, whereas the patients with left hemisphere damage made frequent errors. Within the groups of patients with left hemisphere damage, approximately half showed evidence of apraxia; of these, 25% showed impairments when manipulating the actual tools (75). Based on these observations, Liepmann proposed that the left hemisphere, specifically the parietal region, was responsible for the skilled production of both hands (75). He argued that the right hemisphere depends on the plans and directives of the left hemisphere for learned movement and that the right hemisphere receives movement planning information from the left hemisphere via the corpus callosum. Liepmann proposed the existence of movement formulae, which he defined as knowledge of the course of action (time-space sequences) required to complete an action goal as well as the semantic information about the tool and object used. The movement formulae may be implemented by retrieval of innervatory patterns (configurations of neural connections specialized for particular movement patterns) that communicate directly with the motor system for movement production (75).
Additionally, further support for Liepmann's proposal that the left hemisphere was responsible for the skilled movements of both hands was found in the case described by Liepmann and Maas of a patient with a lesion of the corpus callosum who was unable to produce skilled movements with his nonparalyzed left hand (76). He was unable to write and could not even bring his hand into the writing position. The patient also showed deficits in using actual tools and objects. Liepmann hypothesized that the effect of the corpus callosum lesion in this case was to disconnect the movement formulae of the left hemisphere from the primary motor cortex of the right hemisphere (76).
Subsequently, Liepmann (74; 75) described 3 subtypes of apraxia: (1) limb kinetic apraxia, (2) ideokinetic or motor apraxia, and (3) ideational apraxia. Limb kinetic apraxia was described as a loss of the kinetic components of engrams resulting in coarse or unrefined movements with movements that no longer have the appearance of being practiced over time. Ideokinetic or ideomotor apraxia was described as a loss of ability to perform learned movements. Ideational apraxia was described as an impairment of ideational (conceptual) knowledge resulting in loss of the conceptual linkage between tools and their respective actions as well as the ability to sequence correctly produced movements (74; 75). Integral movements may be left out of a series or produced in the wrong order, or correct movements may be produced with the wrong tools. By describing these praxis subtypes, Liepmann proposed that praxis is supported by a multicomponential system that can be differentially impaired (74; 75). Because Liepmann had used the term ideational apraxia for either the incorrect selection of a tool for a desired action or the incorrect sequencing of actions for a multi-step task, inconsistent use of the term continues to the present (51).
Other subtypes of motor apraxia were subsequently described in the 20th century and include:
• callosal apraxia
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