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  • Updated 05.14.2022
  • Released 02.01.1995
  • Expires For CME 05.14.2025

Congenital toxoplasmosis

Introduction

Overview

Toxoplasma gondii is an important cause of congenital infections. When the infection occurs during pregnancy, the parasite can cross the placenta and severely damage the fetus, where the fetal brain and retina are particularly vulnerable. Microencephaly, intellectual disability, vision impairment, hydrocephalus, and epilepsy are common outcomes. It is critically important to diagnose congenial toxoplasmosis. Left untreated, the infection can cause ongoing brain and retinal injury in the infant.

Key points

Toxoplasma gondii is an intracellular parasite that can gravely damage the human brain and retina when infection occurs during pregnancy.

• The severity of fetal pathology is greatest when maternal infection occurs early in pregnancy, but likelihood of transmission to the fetus is greatest when maternal infection occurs in later pregnancy.

• Classic signs of congenital toxoplasmosis infection include intrauterine growth retardation, liver dysfunction, rash, chorioretinitis, and intracranial calcifications.

• Congenital toxoplasmosis is most commonly diagnosed serologically but can also be diagnosed by real-time PCR or by the detection of parasites in fetal tissues.

• Newborns with suspected or confirmed congenital toxoplasmosis should be treated with a combination of pyrimethamine, sulfadiazine, and folinic acid for 1 year.

Historical note and terminology

Toxoplasma gondii, an obligate intracellular parasite, was first observed in 1908 in cells from the spleen and liver of the gondii, a North African rodent, from which the parasite derives its name. Twenty years later, chorioretinitis was recognized as a complication of human infection with T gondii. In 1939, observations linked congenital toxoplasmosis to intrauterine transmission of the parasite. The first serologic tests for toxoplasmosis were developed in 1948. It was not until the 1960s that cats were identified as the principal host of T gondii and the vector through which the pathogen most commonly reaches humans. In the mid-1970s, it became recognized that past infection with toxoplasmosis could reactivate in immunocompromised patients. Today, toxoplasmosis is recognized as one of the most common and important of the prenatal infections and accounts for the “TO” in the “TORCH” acronym guiding physicians in the workup of suspected congenital infections.

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