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  • Updated 01.18.2021
  • Released 12.30.2014
  • Expires For CME 01.18.2024

Hippocampal atrophy in epilepsy



In this article, the authors present data and discussion about the causes, syndromes, diagnosis, and management of hippocampal atrophy and epilepsy.

Key points

• Hippocampal atrophy is the most important MRI finding in histologically proven hippocampal sclerosis, particularly when associated with hyperintense signal in T2-weighted MRI sequences.

• Hippocampal atrophy associated with mesial temporal lobe epilepsy is 1 of the most frequent forms of epilepsy with focal onset.

• Some patients have an excellent response to antiseizure medication treatment, whereas most patients are pharmacoresistant.

• Surgical treatment yields better seizure control than medical treatment in those who failed initial antiseizure medication treatment.

• There is evidence that hippocampal atrophy progresses over time; however, most of the hippocampal damage is most likely caused by an early insult that may precede seizure onset.

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