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  • Updated 10.26.2023
  • Released 04.10.1995
  • Expires For CME 10.26.2026

Spontaneous carotid and vertebral artery dissection



Cervical artery dissection is the most common cause of ischemic stroke in young adults. Recent prospective studies and clinical trials provide insights into the pathophysiology, risk factors, management, and outcome of this condition. In this article, the authors provide a comprehensive review of spontaneous (nontraumatic) carotid and vertebral artery dissections.

Historical note and terminology

The first description of spontaneous dissection of the cervical arteries dates back to 1915 (153). In 1959, Anderson and Schechter were the first to clearly document a case of spontaneous dissecting aneurysm of the internal carotid artery (04). The term "dissection," from the Latin verb disseco, implied the separation of anatomic structures along the natural lines by tearing of the connective tissue framework. As it is applied to vascular pathology, it relates to the separation of the different layers that constitute the arterial wall. This process can occur either spontaneously or following blunt trauma to the vessel. Sub-intimal dissections can cause lumen stenosis, and sub-adventitial dissections can cause aneurysmal dilatation. Strictly speaking, the lesion of dissection is a “dissecting aneurysm” and includes layers of the normal vessel wall (66). The term “pseudoaneurysm” is often used incorrectly for this same purpose, but this term refers to lesions that do not include components of the normal vessel wall. An example of pseudoaneurysm is a posttraumatic event where the vessel wall is severed and adjacent connective tissue maintains a lumen.

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ISSN: 2831-9125