Osmotic demyelination syndromes
The clinical syndrome of osmotic demyelination develops in hospitalized patients several days after a rapid rise in serum sodium. The clinical features vary, depending on whether the syndrome consists of central pontine myelinolysis, extrapontine myelinolysis, or both. The classical clinical presentation of central pontine myelinolysis (osmotic demyelination syndrome) is progressive, spastic quadriparesis, pseudobulbar palsy, and pseudobulbar affect.
Aug. 26, 2019