Chorea in Wilson disease

Gulf War syndrome

Treatment of neurologic disorders with marijuana

Endocannabinoid receptors are found throughout the CNS, with postsynaptic cannabinoid ligands that act presynaptically on endocannabinoid receptors, which appears to function as a negative feedback system. Multiple sclerosis has the most robust evidence for the efficacy of cannabis, and there is some research suggesting cannabis may suppress seizures in epilepsy, with some clinical trials suggesting benefit in specific pediatric epilepsy syndromes.