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This patient demonstrates "festinating" speech (rapid stuttering). (Contributed by Dr. Joseph Jankovic.)
Neuro-Ophthalmology & Neuro-Otology
Feb. 09, 2021
Neuropharmacology & Neurotherapeutics
Mar. 06, 2021
Childhood CNS immune-mediated vasculitides include a broad spectrum of rare immune-mediated disorders, defined pathologically by inflammation of the vascular wall and resulting in tissue ischemia, necrosis, and inflammation. Irreversible neurologic impairment commonly occurs in this population. As these disorders may be amenable to treatment, prompt recognition by the practicing clinician has the potential to improve clinical outcomes.
Aug. 06, 2020
Ptosis is the defining feature of progressive external ophthalmoplegia, typically with symmetrical and progressive limitation of eye movements, with normal pupils. It is often accompanied by disorders of organ systems other than extraocular muscles. Most cases are inherited, some autosomal, and many are caused by mutations of mitochondrial DNA.
Oct. 13, 2020
Whipple disease is a treatable, multisystem disease caused by infection with Tropheryma whipplei. Whipple disease of the central nervous system may be primary (ie, without evidence of disease outside of the brain) or secondary, occurring in the context of a multisystem condition. Cognitive changes, supranuclear ophthalmoplegia, and altered levels of consciousness are the most common neurologic features.
Dec. 18, 2018
The retinopathies and choroidopathies are a group of eye conditions that can cause central and peripheral visual loss, fundus changes, and electrophysiologic changes. Key signs of retinal disease are positive photostress test, minimal Marcus Gunn pupil in the involved eye, and maculopathies or retinitis pigmentosa on visual field test. Retinal imaging modalities such as optical coherence tomography can help identify retinal disorders and distinguish them from optic nerve disorders.
Jul. 25, 2020
Papilledema is optic disc swelling due to axoplasmic stasis caused by raised intracranial pressure. It is typically associated with symptoms of elevated intracranial pressure, such as headaches, pulsatile tinnitus, and transient visual obscurations. The visual hallmarks are relatively spared visual acuity in the setting of bilateral optic disc edema with enlarged blind spots, nasal visual field loss, or constriction of the visual fields.
Jul. 08, 2018
Nausea and vomiting occur from a large variety of causes and diseases involving several systems, including some neurologic disorders. Nausea is an imminent desire to vomit, whereas vomiting is the oral expulsion of gastric contents. Investigation of vomiting includes consideration of neurologic and gastrointestinal disorders as well as system diseases or the action of drugs or toxins.
Jul. 09, 2021