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Meniere syndrome …
- Updated 05.24.2024
- Released 12.07.2004
- Expires For CME 05.24.2027
Meniere syndrome
Introduction
Overview
The author discusses the clinical presentation, pathophysiology, diagnostic workup, and management of Meniere syndrome. Meniere disease can be confused with migraine-associated vertigo, and current diagnostic criteria may not adequately differentiate the two in all patients. Although some analytic epidemiologic studies have suggested an association between migraine and Meniere disease, more recent studies have not found an elevated incidence of migraine headache in patients with Meniere syndrome compared to the general population. A low-sodium diet and diuretics are considered the mainstays of treatment for Meniere disease. Ablative therapy is a second-line treatment approach for failures of medical therapy. Among the various forms of ablative therapy, the most common are intratympanic aminoglycoside administration and vestibular neurectomy.
Key points
• The key clinical features of Meniere syndrome are recurrent episodes of spontaneous vertigo, fluctuating hearing loss, aural fullness, and subjective tinnitus, with a progressive loss of audiovestibular function. The vertiginous episodes typically last hours (with a range generally of 30 minutes to 12 hours), with residual nonvertiginous disequilibrium lasting possibly several days. | |
• With otolithic crises (also called “otolithic catastrophe”), patients may report the sensation of being suddenly thrown to the ground without warning. | |
• Audiometry is essential for diagnosis, staging, and monitoring. | |
• Caloric tests and either electronystagmography or video nystagmography are recommended, particularly before and after surgical treatment or aminoglycoside therapy. | |
• In at least two thirds of patients, vertigo is successfully controlled with medical management and the natural history of the disease, and many individuals reach a steady-state phase of the disease. | |
• Most studies report a frequency of bilateral disease of between 10% and 33%. | |
• A family history of Meniere disease is convincing (confirmed or probable) in nearly a quarter of patients, and genetic studies suggest that Meniere disease may be transmitted as an autosomal dominant trait with reduced penetrance and anticipation. | |
• Staging is based on the average of pure-tone thresholds at 0.5 kHz, 1 kHz, 2 kHz, and 3 kHz of the worst audiogram in the 6-month period prior to treatment. | |
• The aims of management of Meniere disease are to (1) reduce the number and severity of acute vertiginous attacks and their associated symptoms (eg, hearing loss and tinnitus), (2) alleviate chronic symptoms (eg, hearing loss and tinnitus), and (3) prevent progression of the disease and its associated symptoms (eg, hearing loss and tinnitus). | |
• A low-sodium diet and diuretics are considered the mainstays of treatment for Meniere disease. | |
• Ablative therapy is a second-line treatment approach for failures of medical therapy. Among the various forms of ablative therapy, the most common are intratympanic aminoglycoside administration and vestibular neurectomy. |
Historical note and terminology
In 1861 French otologist Prosper Meniere (1799-1862) described a group of 11 patients, mostly young men in their 30s and 40s, with recurrent episodes of vertigo, deafness, and tinnitus with associated nausea, vomiting, gait ataxia, and falls (34; 158; 261; 09; 80; 222; 179; 06; 21; 163; 150).
The intermittent vertigo attacks were accompanied by diminution of hearing and increased tinnitus. Only one case had mention of aural pressure and fullness, but Meniere did not include this as part of the clinical description. Over time, the hearing loss progressively worsened. He localized the responsible lesion to the peripheral vestibular apparatus and, specifically, the semicircular canals.
Meniere’s localization of responsible pathology to the semicircular canals was apparently based in part on a controversial autopsy (158; 08; 261; 222; 179). Meniere seemed to suggest hemorrhage into the semicircular canals as the responsible pathology, but subsequent historians have carefully reviewed his 1861 report (and an earlier published comment) and have concluded that Meniere was using a separate case of hemorrhage into the semicircular canals to support his contention that the disease was localized to the peripheral cochleo-vestibular system rather than the central nervous system (179).
In 1874 French neurologist Jean Martin Charcot (1825-1893) labeled the disease “Maladie de Meniere” and noted that episodic symptoms ceased when the deafness became complete (34).
Surgical treatments for Meniere disease began in the 1900s. In 1904, Richard Lake at the Royal Ear Hospital in London performed a labyrinthectomy and radical mastoidectomy on a 21-year-old woman with a 5-year history of episodic vertigo, nausea, vomiting, deafness, and tinnitus. In 1928, American neurosurgeon Walter Dandy (1886-1946) described nine cases of intracranial auditory nerve section for Meniere disease: all of the cases survived, and all had symptomatic relief (49).
In 1938, endolymphatic hydrops was found to be the pathological correlate of Meniere syndrome (90; 178), a finding subsequently confirmed by other investigators (91; 92; 178). The initial discovery was made independently by English otologist Charles Skinner Hallpike (1900-1979) and Australian-born neurosurgeon Hugh Cairns (1896-1952) in England, and Japanese otolaryngologist Kyoshiro Yamakawa (c1891-1980) in Japan (178).
Meniere disease is generally defined as the idiopathic syndrome of endolymphatic hydrops, whereas the term Meniere syndrome is generally used for patients with the same clinical features but an identified cause. Other authors, however, use the term Meniere disease for both idiopathic and secondary cases (175; 176).
So-called delayed endolymphatic hydrops develops in an ear that was previously damaged, usually from a bacterial or viral infection. A number of variants of Meniere disease have also been proposed, including vestibular and cochlear Meniere disease (characterized, respectively, by isolated episodes of vertigo or hearing loss, without the complete Meniere syndrome); however, there are no clinical-pathologic studies correlating isolated vestibular and auditory disorders with selective endolymphatic hydrops of the vestibular and auditory labyrinth.
Clinical manifestations
Presentation and course
• The key clinical features of Meniere syndrome are recurrent episodes of spontaneous vertigo, fluctuating hearing loss, aural fullness, and subjective tinnitus, with a progressive loss of audiovestibular function. | |
• In Meniere syndrome, the vertiginous episodes typically last hours (with a range generally of 20 minutes to 12 hours), with residual nonvertiginous disequilibrium lasting possibly several days. | |
• In Meniere syndrome, vertigo may be severe and prostrating, with associated autonomic manifestations (eg, nausea, vomiting, diaphoresis, pallor, hypertension, tachycardia). | |
• In Meniere syndrome, hearing loss is classically described as fluctuating, particularly early in the disease course, but not all patients have fluctuating hearing loss. | |
• In Meniere syndrome, the tinnitus is subjective, classically described as a low-frequency “buzz” or “roar,” but patients may develop a high-pitched component late in the disease. | |
• In Meniere syndrome, aural fullness incorporates sensations of pressure, discomfort, or fullness in the ears. | |
• With otolithic crises (also called “otolithic catastrophe” or "Tumarkin attacks"), patients may report the sensation of being suddenly thrown to the ground without warning. |
The key clinical features of Meniere syndrome are recurrent episodes of spontaneous vertigo, fluctuating hearing loss, aural fullness, and subjective tinnitus, with a progressive loss of audiovestibular function. The vertiginous episodes typically last hours (with a range generally of 20 minutes to 12 hours), with residual nonvertiginous disequilibrium lasting possibly several days (171; 176; 157; 18; 19). About a quarter of patients have vertiginous attacks lasting less than 1 hour, 50% have attacks lasting 1 to 2 hours, and a quarter have attacks lasting more than 2 hours (176). Vertigo may be severe and prostrating, with associated autonomic manifestations (eg, nausea, vomiting, diaphoresis, pallor, hypertension, tachycardia). Hearing loss is classically described as fluctuating, particularly early in the course of the disease, but not all patients have fluctuating hearing loss. Furthermore, the hearing loss is characteristically a low- to midfrequency sensorineural hearing loss (18; 19). The tinnitus is subjective and classically described as a low-frequency “buzz” or “roar” (168), but late in the disease, patients may develop a high-pitched component. Aural fullness incorporates sensations of pressure, discomfort, or fullness in the ears.
Diagnostic criteria for the diagnosis of Meniere disease have been established by the Committee on Hearing and Equilibrium of the American Academy of Otolaryngology--Head and Neck Surgery (05) and subsequently by a consortium of the Classification Committee of the Bárány Society, the Japan Society for Equilibrium Research, the European Academy of Otology and Neurotology (EAONO), the Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS), and the Korean Balance Society (see Tables 1 and 2) (77; 139; 140; 190). These criteria have evoked some criticism (85). Similar criteria have been established by other professional societies (157; 18; 19).
Table 1. Diagnostic Criteria for Definite Meniere Disease
A. At least two spontaneous episodes of vertigo, each lasting 20 minutes to 12 hours. | ||
1. Vertigo is considered to be a “sensation of self-motion when no self-motion is occurring, or the sensation of distorted self-motion during an otherwise normal head movement”. | ||
2. This does not include episodes of nonvertiginous dizziness and unsteadiness, brief or very prolonged episodes of vertigo (which should raise suspicion for other diagnostic possibilities), or provoked episodes of vertigo, such as with sound (Tullio phenomenon) or pressure (Hennebert sign). Provoked episodes of vertigo usually occur late in the course of the disease and are not part of the diagnostic criteria. | ||
B. Low-frequency (125 to 250 Hz) to medium-frequency (500 to 2000 Hz) sensorineural hearing loss, documented audiometrically. | ||
1. Low- to medium-frequency sensorineural hearing loss is defined as increases in pure-tone thresholds for bone-conducted sound that are worse in the affected ear than the contralateral ear by at least 30 dB HL at two contiguous frequencies below 2 KHz. | ||
2. In cases with bilateral low-frequency sensorineural hearing loss, the absolute thresholds for bone-conducted sound must be 35 dB or higher at two contiguous frequencies below 2 KHz. | ||
C. Fluctuating aural symptoms (ie, hearing, subjective tinnitus, or fullness) in the affected ear(s). | ||
1. Subjective tinnitus may become persistent once hearing loss has become permanent. | ||
D. Not better accounted for by another vestibular diagnosis. |
Table 2. Diagnostic Criteria for Probable Meniere Disease
A. At least two spontaneous episodes of vertigo, each lasting 20 min to 24 hours. | ||
B. Fluctuating aural symptoms (ie, hearing, subjective tinnitus, or aural fullness) in the affected ear(s). | ||
1. Fluctuating symptoms must be reported during the vertigo episodes. | ||
2. Hearing loss is typically sensorineural, but conductive or mixed hearing loss may be observed early in the disease. | ||
C. Not better accounted for by another vestibular diagnosis. |
The diagnosis of Meniere disease must be made separately for each ear for a case to be considered bilateral Meniere disease.
Current diagnostic criteria probably do not represent patients with monosymptomatic presentation or an early stage very well (106), nor do they consider diagnostic modalities other than audiometry. Atypical presentations with normal vestibular function and hearing are diagnostic challenges that delay treatment initiation (95).
In patients with unilateral or asymmetric disease, the degree of low-frequency hearing loss (250 Hz to 1 kHz) in combination with auditory symptoms during attacks reliably identifies the ear with the greater extent of endolymphatic hydrops (87).
Other clinical features of Meniere syndrome and Meniere disease may include diplacusis (ie, perception of the same sound with different pitches in the normal and affected ear), recruitment of loudness (suspected when a patient complains that loud sounds are annoying or painful in the ear with poor hearing), a positive Romberg test (although the direction of fall may vary, either toward or away from the affected ear), a positive Fukuda marching test (with significant turning if the patient can stand with eyes closed), Tullio phenomenon (ie, sound-induced vertigo, sound-induced nystagmus, or both), Hennebert sign (ie, pressure-induced vertigo, pressure-induced nystagmus, or both elicited by insufflation of the external auditory canal) (165), a positive Dix-Hallpike test for positioning vertigo (in patients with secondary positioning vertigo), and Tumarkin otolithic crises (ie, drop attacks without warning, associated autonomic or neurologic symptoms, loss of consciousness, or postictal signs) (28; 13; 125; 242; 200; 120). With unilateral disease, the Weber tuning fork test usually lateralizes away from the affected ear, whereas the Rinne test usually indicates better air conduction than bone conduction. Downbeat nystagmus may occur during attacks of Meniere disease due to an asymmetry in the vertical vestibulo-ocular reflex or saccular dysfunction (126).
With otolithic crises (also called “otolithic catastrophe” or "Tumarkin attacks"), patients may report the sensation of being suddenly thrown to the ground without warning. These crises are thought to result from inappropriate stimulation of one of the otolith receptors, probably the saccule (28; 242). Such stimulation causes the brain to interpret the gravity vector as suddenly changing before visual and proprioceptive input can be assessed for accuracy, resulting in a sudden fall (28). Patients with Meniere disease who develop Tumarkin attacks are more disabled, have more severely impaired hearing in the asymptomatic ear (especially at low frequencies), and experience autonomic symptoms that are more severe and more frequent than those without Tumarkin attacks (189; 197). They are also more fearful and anxious, self-report greater impairment in workability, and are more likely to have to apply for work-related disability pensions than Meniere disease patients without Tumarkin attacks (197). Some patients with Tumarkin attacks can also have syncope (196; 198; 197; 120).
Meniere syndrome is a chronic disabling condition with major negative effects on physical and psychosocial functioning and quality of life (236; 121). Anxiety and depression are common in patients with Meniere disease (269; 121). Indeed, in a meta-analysis of 15 studies from eight countries involving 6587 patients, the prevalence of depression in patients with Meniere disease was nearly 50% (185).
Cluster analysis has been used to define subgroups of patients with unilateral Meniere disease (68):
Group 1 (Sporadic, classic Meniere disease), affecting approximately half of patients (53%), without migraine or autoimmune disorder | |
Group 2 (Delayed Meniere disease), affecting 8% of patients, is defined by hearing loss, which antedates the vertigo episodes by months or years, without migraine or autoimmune disorder “in most cases” | |
Group 3 (Familial Meniere disease), affecting 13% of patients | |
Group 4 (Meniere disease with comorbid migraine), affecting 15% of patients | |
Group 5 (Meniere disease with comorbid autoimmune disease), affecting 11% of patients |
There can be some misclassification between groups 2, 4, and 5, as the group 2 definition focuses on a symptom—hearing loss—which antedates the episodes of vertigo, ignoring comorbid conditions. As a result, some individuals with migraine or autoimmune disorders can be included in group 2 rather than in groups 4 or 5, which focus on comorbid conditions irrespective of the presenting symptom.
Meniere disease may also occur with comorbid benign paroxysmal positioning vertigo (BPPV). A meta-analysis found that the pooled frequency of BPPV in Meniere disease is 14% (95% CI 9% to 18%), but the pooled frequency was lower in cross-sectional studies (8%) than in longitudinal studies (38%) (119).
Prognosis and complications
Endolymphatic hydrops tends to worsen over time (263). Hearing thresholds at low frequencies (125 to 250 Hz) and medium frequencies (500 to 2000 Hz) are proportional to the extent of endolymphatic hydrops in the vestibule and cochlea. However, no significant relationship has been demonstrated between the extent of endolymphatic hydrops and other symptoms and signs (eg, high-frequency hearing loss, subjective tinnitus, and aural fullness).
Remissions and exacerbations are typical of Meniere disease, though the frequency of attacks and the severity of associated vegetative symptoms generally decline over a number of years (171; 152; 191). In at least two thirds of patients, vertigo is successfully controlled with medical management and the natural history of the disease, and many individuals reach a steady-state phase of the disease (40; 191). Still, some patients with Meniere disease can have frequent, severe attacks even 20 years or more after disease onset (97).
Estimates of the frequency of bilateral disease vary widely, in part depending on the sensitivity of the method of identifying contralateral disease (171; 70; 124; 180; 43; 35; 188). Most studies report a frequency of bilateral disease of between 10% and 33%, but a wider range is also reported—from 5% to 50% (69). Some studies suggest that individuals with disabling longstanding unilateral disease are unlikely to develop bilateral disease (187). However, the proportion with contralateral disease does increase with disease duration and may approach 50% after 20 years of follow-up (70; 176). Among individuals with bilateral disease, the metachronous form was seen in 76%, and it took a median of 7 years to become bilateral (188). In cross-sectional studies, the disease onset in patients with bilateral disease is earlier than in patients with unilateral disease (35). Psoriasis and a history of ear infection have been identified as key risk factors for developing bilateral Meniere disease (192).
Attempts have been made to identify subgroups of patients with bilateral Meniere disease. One scheme using cluster analysis defined five subgroups: (1) metachronic (ie, not synchronous) hearing loss, without migraine and without associated autoimmune disorders, representing about half of the cases; (2) synchronous hearing loss, without migraine and without associated autoimmune disorders, representing slightly less than a fifth of cases; (3) familial Meniere disease; (4) with associated migraine; and (5) with associated autoimmune disorders—with the latter three categories each representing about 10% of cases (69).
Staging of Meniere disease is based on the average of pure-tone thresholds at 0.5 kHz, 1 kHz, 2 kHz, and 3 kHz of the worst audiogram in the 6-month period prior to treatment (see Table 3) (05). Staging is only done on cases with certain or definite Meniere disease. For reporting purposes, the stage does not change if hearing changes after treatment.
Table 3. Staging of Meniere Disease
Stage |
Pure-tone average (dB) |
1 |
< 26 |
Disability, according to the Committee on Hearing and Equilibrium (05), is best measured by standard functional scale, with the patient making the final selection of disability level (see Table 4). The scale assesses the current state of overall function, not just function during attacks.
Table 4. Functional Level Scale for Meniere Disease
Level |
Description |
1 |
Dizziness has no effect on activities. |
2 |
Episodic dizziness requires briefly stopping activities, but patient continues to work, drive, and participate in activities without restriction and has not changed plans or activities to accommodate dizziness. |
3 |
Episodic dizziness requires briefly stopping activities, but patient continues to work, drive, and participate in activities without restriction, although he or she has had to change plans or activities to accommodate dizziness. |
4 |
Patient is able to work, drive, care for family, and participate in most essential activities but must exert considerable effort to do so and must constantly make adjustments in activities and budget energy. |
5 |
Patient is unable to work, drive, care for family, or participate in most activities previously engaged in. Even essential activities are limited. |
6 |
Patient has been disabled for at least 1 year or receives disability payments because of dizziness or disequilibrium. |
At each office visit, the following should be recorded: the frequency of definitive episodes for the previous 6 months, the pure-tone average (for thresholds at 0.5 kHz, 1 kHz, 2 kHz, and 3 kHz), word recognition scores, and the functional level (05).
Meniere disease is independently associated with an increased risk of injuries (262); medical or surgical treatment for Meniere disease does not reduce the risk of injury in these patients.
Biological basis
• Endolymph is normally absorbed in the endolymphatic duct and sac. | |
• Endolymphatic hydrops is thought to be the pathological substrate of Meniere syndrome, resulting from defects in endolymph absorption. | |
• Endolymphatic hydrops refers to increased hydraulic pressure within the endolymphatic system of the inner ear, causing pathologic dilation of the endolymphatic system and an increased volume of endolymph. | |
• Not all patients who have endolymphatic hydrops pathologically had clinical Meniere syndrome during life. |
Etiology and pathogenesis
Endolymphatic hydrops. Endolymph is normally absorbed in the endolymphatic duct and sac. Endolymphatic hydrops is thought to be the pathological substrate of Meniere syndrome, resulting from defects in endolymph absorption. Endolymphatic hydrops refers to increased hydraulic pressure within the endolymphatic system of the inner ear, causing pathologic dilation of the endolymphatic system and an increased volume of endolymph. However, although endolymphatic hydrops is almost universally present on pathological examination of temporal bones from patients with Meniere syndrome who die, not all patients who have endolymphatic hydrops pathologically had clinical Meniere syndrome during life (203).
A critical review concluded that (1) the preponderance of evidence suggests that endolymphatic hydrops is responsible for some of the auditory symptoms of Meniere disease; (2) Meniere disease should be considered part of a larger spectrum of "hydropic inner ear disease" that also includes some cases without vertigo; and (3) endolymphatic hydrops is a hallmark defining feature of Meniere disease and a sensible target for diagnostic detection (76).
Etiologic factors. The etiology is probably multifactorial in most cases, with a genetic predisposition and environmental triggers, such as infection, cranial or otic trauma, otitis media, viral infection, syphilis, otosclerosis, etc. (81; 175; 72; 99; 146; 61).
Genetics. Most cases are sporadic, but familial aggregation has been recognized in European and Korean populations (138). The presence of familial cases suggests that shared environmental exposures or genetic factors are important in the etiology (99). A systematic investigation of the family histories of a large set of patients affected with Meniere disease found that a family history of Meniere disease was convincing (confirmed or probable) in nearly a quarter (23.4%) of the patients (99).
Genetic studies suggest that Meniere disease may be transmitted as an autosomal dominant trait with reduced penetrance and anticipation (07); a candidate region has been located on chromosome 5 (07). Genes associated with familial Meniere disease include COCH, FAM136A, DTNA, PRKCB, SEMA3D, and DPT (138). Rare deletions in the ERBB3 gene or large duplications covering the AP4M1, COPS6, MCM7, TAF6, MIR106B, MIR25, and MIR93 genes contribute to genetic variation in patients with severe tinnitus and Meniere disease (61).
In a study of the genetic etiology of Meniere disease using next-generation sequencing in three families, seven rare variants were identified to cosegregate with Meniere disease: one variant in the CYP2B6 gene in family I, one variant in GUSB and EPB42 in family II, and one variant in each of the SLC6A, ASPM, KNTC1, and OVCH1 genes in family III (229): dysfunction of CYP2B6 and SLC6A may predispose to Meniere disease via the oxidative stress pathway, where dysfunction of ASPM and KNTC1 may produce dysregulation of mitotic spindle formation.
The finding of rare mutations in TECTA, MYO7A, and OTOG genes and other genes (eg, CDH23, PCDH15, and ADGRV1) in the same families suggest that the integrity of the stereocilia and their interaction with the tectorial and otolithic membranes may be involved in the pathophysiology of familial Meniere disease (48; 67; 182; 183). A heterozygous likely pathogenic variant in the OTOG gene (rs552304627) was found in two unrelated families (206; 141).
Immunology. Immunologic contributions have also been proposed based on higher rates of autoimmune disorders (eg, rheumatoid arthritis, systemic lupus erythematosis, ankylosing spondylitis, atopic dermatitis, vitiligo) in cases than controls (53; 74; 88; 142). At least two inflammatory mechanisms have been involved in Meniere disease: (1) a proinflammatory immune response mediated by interleukin-1 beta, tumor necrosis factor alpha, and IL-6; and (2) a nuclear factor-kappa B-mediated inflammation in the carriers of the single-nucleotide variant rs4947296 (138).
Membrane rupture theory. In the 1960s and later, Schuknecht proposed the “membrane rupture theory” (216; 217; 218), which continues to be popular and has many adherents (201). According to this theory, episodes of vertigo in Meniere syndrome result from breaks in the pathologically dilated membrane that separates the potassium-poor perilymph from the potassium-rich endolymph. The resultant mixture of fluids bathes the vestibular receptors, causing acute depolarization and transient increased function, followed by depolarization blockade and transient loss of function. Symptoms gradually improve as the membrane is repaired or stabilized and sodium and potassium concentrations return to normal.
Problems have been noted with the “membrane rupture theory”: (1) careful pathologic studies have found no evidence of membrane rupture in a significant proportion of patients (176); (2) the initial symptoms and progression of symptoms do not correlate well with pathologically identified ruptures (176); (3) electronystagmographic monitoring has demonstrated that the initial nystagmus during an attack of Meniere syndrome is a paralytic nystagmus beating away from the affected ear, followed by an “irritative-like” secondary nystagmus beating toward the affected ear (154; 153; 33; 181), whereas the initial nystagmus according to the “membrane rupture theory” should be an irritative nystagmus beating toward the affected ear with later development of a paralytic nystagmus as the lesion heals (59). However, the problem is that the irritative nystagmus is brief and typically missed, and an additional phenomenon is not considered, ie, recovery nystagmus.
Irritative nystagmus. Although other labyrinthine disorders typically produce a "paralytic" nystagmus beating toward the "good" ear, in Meniere disease, there can be an excitatory phase with so-called "irritative" nystagmus beating toward the "bad" ear, followed by an inhibitory phase beating toward the "good" ear (14; 27). Meniere disease may, thus, present with nystagmus that reverses direction over a period of minutes, reflecting initial irritative nystagmus giving way to paralytic nystagmus.
Bery and Chang presented a case report with video documentation to document the serial changes in nystagmus characteristics in a patient with Meniere disease during and after an acute attack (27). A 65-year-old woman with right-sided Meniere disease had frequent vertigo attacks associated with fluctuating right-sided tinnitus, hearing loss, and vomiting for a period of 6 months. The attacks were spontaneous, occurred every 1 to 2 days, and lasted around 2 hours. She experienced one of these attacks during eye movement recording. She initially demonstrated right-beating nystagmus (that is, beating toward the affected ear), but after 2 minutes, the nystagmus gradually reversed and became left-beating (that is, beating toward the good ear). During the reversal, she had transient downbeat nystagmus. The left-beating nystagmus persisted for 2 hours. The case, including the excellent video documentation and supplementary materials, provides an excellent example of the changing character of nystagmus that can be seen in Meniere disease.
The very transient nature of the "irritative" nystagmus during the excitatory phase is one reason many clinicians doubted that an irritative component exists as part of Meniere disease.
Recovery nystagmus. So-called "recovery" nystagmus may also occur after a period of several days, again beating toward the "bad" ear as in the initial "irritative" nystagmus (154; 153). Recovery nystagmus occurs after a unilateral peripheral vestibular lesion, when nystagmus transiently reverses direction as some function is restored in the damaged labyrinth (154; 153). This reflects the effects of a restoration or partial restoration of peripheral vestibular inputs after compensatory central rebalancing of the vestibular nuclei has already occured.
Alternative theories. A number of alternative theories have been proposed, including Tonndorf’s concept that attacks are precipitated by mechanical membranous distortions resulting from sudden increases in endolymphatic pressure (243). In patients with endolymphatic hydrops, pressure fluctuations in the dilated endolymphatic system stress the nerve-rich structures of the inner ear, causing Meniere syndrome. The observed diphasic pattern of nystagmus is explained by (1) an initial disruption of ipsilateral vestibular function causing a paralytic nystagmus beating away from the affected side, (2) subsequent central adaptation dampening or resolving the initial paralytic nystagmus, (3) restoration of vestibular function with decline in endolymphatic pressure and resolution of mechanical membrane distortion, and (4) development of secondary “recovery nystagmus” beating toward the affected side as a result of the improved ipsilateral vestibular dysfunction after central compensatory mechanisms had partially or fully rebalanced the neural discharges from both sides (154; 153; 33; 181).
There is some evidence for the involvement of ion homeostatic or blood-labyrinthine barrier dysfunction in human temporal bones: immunohistochemistry staining to detect known protein expression related to ionic homeostasis and barrier function in the cochlea showed that expression of KCNJ10 was significantly reduced in all cochlear regions, including the stria vascularis, and CLDN11 and CLU expression was significantly reduced in spiral ganglion neurons (110).
Chamber configuration and progression of endolymphatic hydrops. Chamber configuration may be a factor controlling the progression of endolymphatic hydrops in Meniere disease (186). Considerable disparities in pressure-induced membrane stress exist among the vestibular chambers due to variations in membrane shape, size, and thickness (186). The thick and highly curved membranes in the semicircular ducts produce low stress levels, whereas the thin and relatively flat membranes in the saccule produce high stress levels (186).
Familial Meniere disease. Familial Meniere disease has been reported in 6% to 9% of sporadic cases, and mutations in various genes (eg, FAM136A, DTNA, PRKCB, SEMA3D, and DPT) and involvement of different structural proteins in the cochlear hair cell stereocilia have been implicated in single families, suggesting genetic heterogeneity (206; 182). One heterozygous likely pathogenic variant in the OTOG gene (rs552304627) was found in two unrelated families (206).
Proteins and their coding genes are listed for the stereocilia links (tip links, horizontal top connectors, shaft connectors, and ankle links) and between the stereocilia and the tectorial membrane. In addition, proteins that a...
Epidemiology
• Meniere syndrome and Meniere disease are common disorders that are estimated to affect more than 2 million people in the United States. |
Meniere syndrome and Meniere disease are common disorders that are estimated to affect more than 2 million people in the United States. According to some studies, males and females are affected about equally (171), whereas other studies reported that females are two or three times more likely than males to develop Meniere disease (35; 03; 115). Age of onset varies widely from 7 to 75 years of age, with onset typically from 30 to 60 years of age (171; 35; 252). Meniere disease is reported to have a prevalence of 200 to 500 per 100,000 (86). Although the reported prevalence of Meniere syndrome varies widely in different studies, the prevalence of Meniere syndrome generally increases with increasing age (03).
In South Korea, annual incidence rates increased rapidly from 2013 to 2017 and showed a seasonal pattern with higher incidence rates in summer and autumn than in winter and spring (115).
Putative underlying etiologies and attack triggers have been mostly identified anecdotally, or presumptively determined in case series, but a few analytic epidemiological studies have been performed. Emotional stress increases the probability of an attack during the next hour and possibly during the next 3 hours (230).
The frequency of migraine in Meniere disease is higher than in normal subjects (211). Moreover, the high frequency of migraine symptoms on the same side as the ear affected by Meniere disease suggests a shared pathophysiology in both Meniere disease and migraine (239).
A systematic review and meta-analysis of observational case-control studies using molecular-diagnostics assessed the role of viral infections in the etiology of Meniere disease: 14 studies involving 611 cases with Meniere disease and 373 controls were included (50). Most of the included data concerned the human cytomegalovirus, and meta-analysis of eligible studies showed that evidence of cytomegalovirus infection was associated with an approximately 3-fold increased risk of Meniere disease, although the timing of the infections relative to Meniere disease onset was indeterminate. No association was found for herpes simplex virus 1 or 2 (HSV-1, HSV-2), varicella zoster virus, or Epstein-Barr virus.
In a retrospective population-based case-control cohort study using data from the Korean National Health Insurance Service database, subjects with Meniere disease were compared with a matched cohort without Meniere disease who were enrolled randomly and matched for sex, age, year of diagnosis, income level, and residential area (114): no significant differences were observed between the groups in the incidence of autoimmune diseases, cerebrovascular disease, or cardiovascular disease.
Prevention
No information is available on prevention of Meniere disease.
Differential diagnosis
Confusing conditions
The diagnosis of Meniere disease depends on careful application of the clinical diagnostic criteria (05). Meniere disease should not be confused with recurrent vestibulopathy without auditory symptoms, vestibular neuritis (typically with a single episode of vertigo lasting days followed by recovery, even with persistent hearing loss and tinnitus), benign paroxysmal positioning (or positional) vertigo (with brief episodes of positioning-induced vertigo lasting less than 1 minute without associated auditory symptoms), or stuttering progression of sensorineural hearing loss (with or without tinnitus) in the absence of vestibular symptoms.
Meniere disease can be confused with vestibular migraine (58; 201; 136; 163; 265), and current diagnostic criteria may not differentiate the two adequately in all patients (201; 136). Episodic vertigo lasting hours and associated headache may indeed occur with both conditions. Many cases of so-called vestibular Meniere disease probably have migraine-associated vertigo instead. Vestibular symptoms during attacks combined with the results of vestibular function tests may be used to differentiate between vestibular migraine and Meniere disease (265). For example, a reduced vestibular response with caloric testing is supportive of Meniere disease rather than migraine-associated vertigo (58; 265). Some analytic epidemiologic studies have suggested an association between migraine and Meniere disease (201), but it is still unclear whether migraine can cause inner ear damage that progresses to development of endolymphatic hydrops, or whether migraine can in some cases mimic Meniere syndrome. Furthermore, other studies have not found an elevated incidence of migraine headache in patients with Meniere syndrome compared to the general population (78).
Associated or underlying disorders
Meniere syndrome may occur with a variety of conditions that interfere with normal production or resorption of endolymph and might result in endolymphatic hydrops, including head trauma, ear surgery, infections (eg, mumps, syphilis), endocrine abnormalities (eg, thyroid disease), autoimmune-mediated conditions, and possibly impaired venous drainage resulting from internal jugular vein stenosis or occlusion (82; 177; 223; 57; 209; 31; 64). Otosyphilis may have clinical features that include Meniere syndrome and interstitial keratitis, and pathologic findings of endolymphatic hydrops and vasculitis. Classic Cogan syndrome includes Meniere syndrome and interstitial keratitis but without serologic evidence of syphilis, whereas variant Cogan syndrome includes Meniere syndrome and uveitis (or other ocular inflammation) without serologic evidence of syphilis.
Despite repeated suggestions in the medical literature that thyroid dysfunction predisposes to Meniere disease, there is no definitive evidence for this (105). However, a case-control study using health insurance records found significant associations of goiter, hypothyroidism, and hyperthyroidism with Meniere disease (116).
Diagnostic workup
• Diagnostic evaluation of patients with Meniere syndrome should include audiograms and various tests to exclude potential underlying causes. | |
• Audiometry is essential for diagnosis, staging, and monitoring. | |
• Caloric tests and either video nystagmography or electronystagmography are recommended. | |
• Electrophysiological tests proposed for initial diagnosis or follow-up of patients with Meniere disease include (1) electrocochleography, (2) otoacoustic emissions, and (3) vestibular evoked myogenic potentials. | |
• Brain imaging is generally not necessary unless symptoms and signs support a central nervous system basis for episodic vertigo, but the clinical utility of magnetic resonance imaging for Meniere disease is evolving. | |
• Endolymphatic hydrops is not pathognomic of Meniere disease, and detecting hydrops on MRI does not directly indicate a diagnosis of Meniere disease. |
Diagnostic evaluation of patients with Meniere syndrome should include audiograms and various other tests to exclude various potential causes. Laboratory tests advocated for this purpose include urinalysis and various blood tests, including a complete blood count, electrolytes, serum glucose and hemoglobin A1c, thyroid stimulating hormone, erythrocyte sedimentation rate, antinuclear antibody, serologic tests for syphilis, and Lyme disease antibodies (213; 142).
Audiometry. Audiometry is essential for diagnosis, staging, and monitoring. Audiometric changes do not directly correspond with the vestibular ones, so for therapy planning and diagnosis, both categories of tests are necessary (148).
This should include an audiogram with pure-tone and speech discrimination tests and acoustic reflex decay. Low-frequency or mixed low- and high-frequency hearing loss may be observed, but typically the lower frequencies are most severely affected, giving an upward-sloping configuration (22). Patients with unilateral disease, in particular, demonstrate a characteristic low-frequency hearing loss, even in advanced stages of the disease (22).
Later in the disease, particularly with bilateral disease, a flat loss (ie, affecting all frequencies) or uncommonly a dome pattern (loss in both high and low frequencies, but minimal loss between 500 Hz and 2000 Hz) (171; 22).
Recruitment can be demonstrated by deafness for sounds with weak or medium intensity, but normal hearing or possibly hyperacusis for sounds with greater intensity. Serial audiograms may document fluctuating hearing loss, as well as progressive hearing loss over periods of years (22). Immittance testing demonstrates a normal tympanogram, confirming normal external auditory canal and middle ear function.
Low-frequency air-bone gaps may occur in Meniere disease, a phenomenon that had been puzzling because air-bone gaps are commonly found in patients with conductive or mixed hearing loss due to outer- or middle-ear diseases. Analysis of delayed gadolinium-enhanced MRI suggests that direct contact between the distended saccule and the inner surface of the stapes footplate is the likely underlying pathophysiological mechanism (172).
Caloric tests and video- or electro-nystagmography. Caloric tests and either video nystagmography or electronystagmography are recommended (89; 30; 234), particularly before and after surgical treatment or aminoglycoside therapy (05). Horizontal vestibulo-ocular reflex evaluation with caloric testing (a low-frequency test) is more often abnormal than video-head impulse testing (a high-frequency test) in patients with Meniere disease, but both tests can be used to provide complementary information on peripheral vestibular function (30; 162).
Caloric testing and electronystagmography/video nystagmography should be performed on an empty stomach after discontinuing vestibular sedatives for at least 2 weeks. Canal paresis in Meniere syndrome is thought to result from ampullary distortion and resultant disruption of the cupulary attachment of the horizontal semicircular duct (205). Unilateral canal paresis supports symptomatic dysfunction of the paretic ear. Asymmetric caloric function in the presence of normal horizontal head impulse tests is most commonly associated with Meniere disease, compared with other neuro-otological conditions (96; 170); this dissociation may serve as a useful diagnostic marker (96). Like audiometric test results, caloric response reduction may also fluctuate in patients with Meniere syndrome (04; 152). The caloric test can detect abnormalities of vestibular function better than video head impulse tests in all stages of Meniere disease (133).
Caloric responses fluctuate during and between the attacks of Meniere disease (127). During the irritative and recovery phase, less than half of patients show a caloric asymmetry of more than 25%, whereas patients usually show a caloric asymmetry of more than 25% during the paretic phase, with a decreased response almost always in the affected ear. Between attacks, caloric asymmetry is found in less than half of patients, with a decreased response almost always in the affected ear when observed.
A systematic review and meta-analysis (12 articles, published between 2014 and 2021, with 708 patients evaluated) found that the frequency of an abnormal caloric response in patients with Meniere's disease was 64%, whereas the prevalence of altered vHIT was only 28% (237).
A histopathological study using temporal bone specimens and their corresponding clinical testing data found otolith membrane herniation into the horizontal semicircular canal in 69% of Meniere disease ears, with 90% of these ears demonstrating a diminished caloric response, whereas no ears with a normal response had this herniation (224). In addition, there was no evidence of semicircular canals duct dilation/hydrops. The authors concluded that otolith membrane herniation, not semicircular canal duct dilation, is associated with decreased caloric responses in Meniere disease.
Spontaneous or positional nystagmus is detected on electronystagmography/video nystagmography in about 20% of cases (with some studies reporting values as high as 50%) (152). Although spontaneous nystagmus is supportive of active Meniere syndrome, it does not reliably indicate the side of the lesion (154; 153; 33; 181). Electronystagmographic or video nystagmographic monitoring may be helpful in verifying the affected side by identification of recovery nystagmus (154; 153; 33; 181). Such verification is particularly important when planning surgical procedures for treatment. Ideally, monitoring should include direct eye observation or video nystagmography because pure rotatory nystagmus can occur and will not be detected by electronystagmography (181).
Electrophysiological tests. Electrophysiological tests proposed for initial diagnosis or follow-up of patients with Meniere disease include (1) electrocochleography, (2) otoacoustic emissions, and (3) vestibular evoked myogenic potentials (39). Available data are still limited, and the recommended procedures have not reached an international consensus (39). None of the electrophysiological tests can be considered pathognomonic for the diagnosis of Meniere disease; thus, they need to be considered as having a supportive role in clinical diagnosis (39).
Electrocochleography and otoacoustic emissions may be helpful, though supportive data are limited (149), but the data are not incorporated into current diagnostic guidelines because these tests are not universally available or standardized (05). The presence of endolymphatic hydrops is generally indicated by either an elevated summating/action potential ratio with click stimulation or a depressed summating potential amplitude with tone burst stimulation (266). Suggested thresholds are a summating/action potential ratio with click stimulation greater than 0.35 using transtympanic electrocochleography, a summating/action potential ratio greater than 0.42 using extratympanic electrocochleography, or a summating potential amplitude of less than 2 microvolts for at least one frequency within the range of 0.5 to 0.8 kHz using transtympanic electrocochleography with tone burst stimulation set at a repetition rate of 30 to 40 stimuli per second (266). Electrocochleography may be particularly helpful in excluding contralateral disease before proceeding with destructive surgical procedures; it appears to be more sensitive for detecting contralateral disease than relying on the presence of auditory dysfunction, tinnitus, and aural fullness (43).
Cervical and ocular vestibular-evoked myogenic potentials (cVEMP and oVEMP, respectively) are being studied but have yet to prove to be important in the diagnosis of Meniere disease (259; 277; 250; 63; 122; 147). Preliminary results suggest that cVEMP thresholds can help distinguish Meniere disease from vestibular migraine, and serial cVEMP testing may be a sensitive marker of disease progression in Meniere disease (250). However, according to a Practice Guideline from the American Academy of Neurology, “Evidence is insufficient to determine […] whether vVEMP or oVEMP is useful in diagnosing […] Meniere disease” (63).
Imaging. Brain imaging is generally not necessary unless symptoms and signs support a CNS basis for episodic vertigo, but the clinical utility of MRI for Meniere disease is evolving (15; 86; 220; 12; 83; 233; 25; 137; 143).
Delayed gadolinium-enhanced MRI after intratympanic contrast administration. Endolymphatic hydrops can be demonstrated in vivo by MRI with intratympanic gadolinium contrast administration, and affected ears show variable degrees of impaired perilymphatic enhancement (65; 66; 263; 244; 104). Prior contrast-enhanced MRI techniques used a 3-dimensional fluid-attenuated inversion recovery (FLAIR) sequence after intratympanic gadolinium administration (sometimes after a 4 to 24 hours) (25; 104). Contrast-enhanced MRI after intratympanic gadolinium can reliably and accurately detect and grade Meniere disease (25). However, the need for intratympanic contrast administration has been obviated in some more recent studies.
Delayed gadolinium-enhanced MRI after intravenous contrast administration. Endolymphatic hydrops can now be detected and graded using 3T MR images of the inner ear acquired (1) at least 2 to 4 hours after intravenous contrast administration with a 3D inversion-recovery sequence (15; 25; 108; 132; 173; 184; 249; 16; 93), (2) 6 hours after double-dose intravenous contrast administration with 3D-FLAIR (129), or (3) 24 hours after intravenous contrast administration with a 3D real inversion recovery (3D-real IR) sequence (52). Some reports have emphasized the need for delaying MRI more than 3 hours after intravenous contrast administration (36).
Most imaging studies have been done on a 3-T MRI scanner, and it had been thought that endolymphatic hydrops could only be demonstrated on MRI with a 3-T magnet. However, multiple studies have shown that endolymphatic hydrops can be confidently demonstrated with the current standard 4-hour delayed intravenous gadolinium-enhanced 3D-FLAIR sequence on MRI with a 1.5-T magnet (94; 113).
Sensitivity and specificity. Studies have reported 10% to 33% of patients with Meniere disease do not have MRI-demonstrable changes of hydrops (199; 15; 174). In one study of 54 patients, endolymphatic hydrops was demonstrated in 90% on the clinically affected side and in 22% on the clinically silent side with high levels of interobserver agreement (15).
The combination of perilymphatic enhancement and endolymphatic hydrops in patients suspected of having Meniere disease increases the positive predictive value in diagnosing definite Meniere disease (249).
In the absence of access to MRI with 3D reconstruction of the endolymphatic space, measurements of the saccule on routine nonenhanced 3D-T2 MRI can show hydrops and help diagnose Meniere disease (228; Lopez-Escamez and Attye 2019).
Evaluation of the vestibular endolymphatic space contacting the oval window has high specificity and positive predictive value in differentiating Meniere disease ears from other ears (45). Obliteration of the inferior portion of the vestibule and the contact with the stapes footplate by the vestibular endolymphatic space are reliable markers for diagnosing Meniere disease (45).
MRI may be helpful in the differentiation of Meniere disease and "menieriform diseases" with clinical overlap, including vestibular migraine and vestibular schwannoma (233; 129b; 271). In addition, MRI may reveal brain lesions, semicircular canal abnormalities, and perilymphatic fistulae in patients with clinical Meniere disease (12).
MRI does not yet seem helpful for diagnosing cases of Meniere disease with early symptoms and the reproducibility of the hydrops protocols with various MRI scan manufacturers is debatable, limiting widespread adoption of these techniques into clinical practice (137).
Endolymphatic hydrops is detectable in a high proportion of Meniere disease cases (99%), but it is not specific for Meniere disease. For example, it is present in about half of cases with vestibular schwannoma (48%) and is also present in "healthy" temporal bones (13%) (246). Therefore, endolymphatic hydrops is not a pathognomonic phenomenon, and detecting this on MRI does not directly indicate a diagnosis of Meniere disease.
Staging. Various approaches have been used to stage endolymphatic hydrops overall (159) and to grade cochlear and vestibular components separately (129) while also assessing cochlear and vestibular perilymphatic enhancement (129).
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Endolymphatic hydrops after intravenous injection of gadolinium contrast agent
Structural images of the inner ear showing no, mild, and significant endolymphatic hydrops, after intravenous injection of an ordinary dose of gadolinium (Gd) contrast agent with a 3T MRI. Arrows and arrowheads indicate endolym...
MRI results can be used to classify the degree of endolymphatic hydrops into four stages (84; 26; 104; 129):
Stage 0, no hydrops: no enlargement of the endolymphatic space in the cochlea and vestibule, and the perilymphatic space is clearly visible | |
Stage 1, mild hydrops: the endolymphatic space is enlarged with hypointensity bulging into the perilymphatic space with hyperintensity | |
Stage 2, marked hydrops: the endolymphatic space is enlarged, the scala media is convex to the scala vestibuli, and the perilymphatic space is semicircular | |
Stage 3, extreme hydrops: the endolymphatic space is severely dilated, the scala media continues to be convex to the scala vestibuli, and the perilymphatic space is compressed into a flattened line (84; 104). |
Cochlear hydrops can be classified into three degrees or grades from 0 to 2 (15):
Grade 0, no cochlear hydrops | ||
Grade 1, cochlear hydrops | ||
(a) irregular dilation and partial obstruction of the scala vestibuli | ||
Grade 2, cochlear hydrops | ||
(a) total obliteration of the scala vestibuli | ||
Vestibular hydrops can be classified into four degrees or grades from 0 to 3 (26) by a modification of an earlier three-level grading system (15), with the four-grade system having greater sensitivity to detect Meniere disease while preserving specificity (26):
Grade 0, no vestibular hydrops | |
Grade 1, vestibular hydrops: the saccule, normally the smallest of the two vestibular sacs, is equal or larger than the utricle but is not yet confluent with the utricle | |
Grade 2, vestibular hydrops: dilation of the endolymphatic space encompasses more than 50% of the vestibulum | |
Grade 3, vestibular hydrops: dilation of the endolymphatic space leads to effacement of the perilymphatic space. |
In another approach, vestibular hydrops can be classified into three degrees or grades from 0 to 2 by calculating the ratio of the area of the endolymphatic space to the total area of the endolymphatic and perilymphatic spaces ("R-value") (104):
Grade 0, no vestibular hydrops: R ≤ 1/3 |
The degrees of cochlear and vestibular hydrops are positively correlated (103).
Perilymphatic enhancement is one signature of blood-perilymph barrier impairment (26).
Axial delayed gadolinium-enhanced 3D FLAIR images at the level of the inner ear in a 77-year-old woman with unilateral left-sided definite Meniere disease. There is cochlear hydrops grade 1 (small arrowhead) and vestibular hydr...
Assessment of both endolymphatic hydrops and perilymphatic enhancement improves the diagnostic accuracy for probable and definite Meniere disease (129). In a meta-analysis, the combination of increased perilymphatic enhancement and endolymphatic hydrops (three studies, 122 Meniere disease ears) achieved the highest sensitivity (87%) whilst maintaining high specificity (91%) (44).
Another marker of the blood-labyrinth barrier in Meniere disease is the signal intensity ratio (SIR) of the cochlear basal turn on 3D-FLAIR MRI (276). The SIR of the affected ear in Meniere disease was significantly increased compared to that of the unaffected ear (276). The SIR of the unaffected side in Meniere disease was higher than that of both ears in healthy controls (276). The SIR in the affected ear of Meniere disease was positively correlated with both cochlear and vestibular hydrops (276).
Vestibular aqueduct abnormalities on CT and MRI can be classified into three degrees or grades from 0 to 2 (the original article used A to C, but a numbered approach is used here for overall consistency with grading of cochlear and vestibular hydrops) (11; 270):
Grade 0: Normal with a continuous vestibular aqueduct | |
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Visibility of vestibular aqueduct grading on the Pöschl planes on temporal bone CT
(a) Grade 0 with a continuous vestibular aqueduct (arrow). (b) Grade I with a discontinuous vestibular aqueduct (arrow). (c) Grade II with a complete ossification of vestibular aqueduct. Note: The Pöschl projection is used in i...
The morphology of the vestibular aqueduct in the 45° oblique (Poschl) plane can be classified into funnel, tubular, filiform, hollow, and obliterated types (273; 270).
Peri-aqueductal pneumatization was classified into three levels or grades from 1 to 3:
Grade 1: large-cell peri-aqueductal pneumatization | |
In patients with Meniere disease, visualization of the vestibular aqueduct on 3D-SPACE MRI is poorer than that observed on CT and may be affected by its osseous configuration (270). MRI vestibular aqueduct visualization has a weak positive correlation with ipsilateral CT vestibular aqueduct visualization (270). For the affected side, vestibular aqueduct visualization with MRI was negatively correlated with the frequency of obliterated morphology on CT and positively correlated with that of tubular morphology on CT (270). MRI vestibular aqueduct visualization was not affected by periaqueductal pneumatization on CT (270).
Clinical-radiologic correlation. Symptomatic endolymphatic hydrops visualized on MRI is reliably on the affected side, and asymptomatic endolymphatic hydrops is detected on the unaffected contralateral side in as many as one fifth of cases (132). Analysis of the vestibular aqueduct by MRI detects symmetric abnormalities in both ears in many patients with unilateral Meniere disease (11). Resolution of endolymphatic hydrops on delayed intravenous contrast-enhanced 3D-FLAIR MRI has been demonstrated following acetazolamide therapy (220) and other medical treatments (274).
Pure tone averages and endolymphatic staging are higher for combined vestibular and cochlear endolymphatic hydrops than for isolated cochlear or vestibular hydrops (104). The degree of cochlear hydrops was positively correlated with pure tone averages, low-frequency hearing thresholds, mid-frequency hearing thresholds, and the stage of endolymphatic hydrops (104).
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Relationship between the degree of cochlear endolymphatic hydrops and pure-tone average
According to grading criteria of the 1997 World Health Group, the pure tone average hearing threshold was calculated as the average pure tone audiometry thresholds of binaural air conduction at 500, 1000, 2000, and 4000 Hz (PTA...
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Relationship between the degree of cochlear endolymphatic hydrops and disease staging
Meniere disease staging was obtained by calculating the pure tone average hearing thresholds at 500, 1000, 2000, and 3000 Hz (Committee on Hearing and Equilibrium, American Academy of Otolaryngology-Head and Neck Foundation. Co...
There was no significant correlation between the grade of vestibular endolymphatic hydrops and pure tone averages or the stage of endolymphatic hydrops (104), although other studies have reported associations between vestibular endolymphatic hydrops on MRI and hearing loss (103).
Endolymphatic hydrops detected by MRI shows limited and inconsistent correlation with caloric stimulation results (103; 71).
Bone mineral density assessment. Dual-energy x-ray absorptiometry of the hip and spine (not the heel) is recommended to assess bone mineral density in patients with Meniere disease. Meniere disease is associated with low bone mineral density (osteopenia or osteoporosis) as measured by dual-energy x-ray absorptiometry at the femoral neck (226), and the vertigo and imbalance associated with the disease present a significantly increased risk of falls and falls with injury. To minimize potential fall-related fractures, dual-energy x-ray absorptiometry and monitoring of 25-hydroxy vitamin D levels are recommended.
Other tests. Some authors advocate provocative glycerol or furosemide tests (157); however, the outcome of these tests is highly dependent on patient and provider expectations and suggestion (241).
Management
• The aims of management of Meniere disease are to (1) reduce the number and severity of acute vertiginous attacks and their associated symptoms (eg, hearing loss and tinnitus), (2) alleviate chronic symptoms (eg, hearing loss and tinnitus), and (3) prevent progression of the disease and its associated symptoms (eg, hearing loss and tinnitus). | |
• Current medical management can control vertiginous attacks in approximately 75% to 80% of patients but does not appear to alter the long-term progression of hearing loss. | |
• Initial management of Meniere syndrome involves diagnosis and treatment of the primary disease (eg, thyroid disease). | |
• Chronic management of Meniere disease includes the use of hearing aids and masking devices, lifestyle modification, salt restriction, and diuretic therapy. | |
• The major focus of lifestyle modification is avoiding potential disease triggers, including stress, fatigue, high-salt foods, and other potential trigger substances, although evidence supporting this approach is limited and of low quality. | |
• In patients with Meniere syndrome or Meniere disease, vestibular sedatives, particularly those with anti-emetic or anxiolytic properties, and intravenous fluids may be helpful in decreasing symptoms acutely during an attack. | |
• A low-sodium diet and diuretics are considered the mainstays of treatment for Meniere disease, although evidence supporting this approach is limited and of low quality. | |
• Ablative therapy is a second-line management approach for failures of medical therapy, although evidence supporting this approach is limited and of low quality. | |
• Surgical treatment of Meniere syndrome and Meniere disease is reserved for medical treatment failures but remains controversial as it based on limited poor-quality evidence. | |
• Vestibular rehabilitation is generally recommended after aminoglycoside treatment or surgery, and may be helpful in minimizing disability, particularly in older individuals. | |
• Certain tasks requiring balance and having a high risk of injury with falls (eg, climbing ladders) should generally be avoided. |
The management goals of Meniere disease are to (1) reduce the number and severity of acute vertiginous attacks and their associated symptoms (eg, hearing loss and tinnitus); (2) alleviate chronic symptoms (eg, hearing loss, tinnitus, disequilibrium); and (3) prevent progression of the disease and its associated symptoms (eg, hearing loss, tinnitus, disequilibrium) (40). The treatment plan should be individualized based on the clinical features, including hearing stage, disease duration, vertigo attack profile, and comorbidities (62). Many patients with Meniere disease can be managed using nonablative therapy (eg, medical management, intratympanic steroids, and endolymphatic shunt surgery) before ablative techniques (eg, intratympanic gentamicin and vestibular neurectomy) (38).
A major problem in the management of Meniere disease is the overall poor quality of supporting studies for various treatments (247; 123; 254; 255; 256; 257; 258). Even many systematic reviews and meta-analyses in this field show a lack of rigor. Few existing clinical guidelines meet the standards of quality established by the AGREE II appraisal instrument (17). In addition, the placebo effect in Meniere disease trials is associated with some symptomatic improvement in subjective outcomes, such as patient-reported vertigo episodes (238).
Treatment of Meniere disease can be considered in terms of acute phase management and management of recurrent intermittent presentations (159).
(Source: Mohseni-Dargah M, Falahati Z, Pastras C, et al. Meniere's disease: Pathogenesis, treatments, and emerging approaches for an idiopathic bioenvironmental disorder. Environ Res. 2023;238[Pt 1]:116972. Creative Commons Att...
Acute-phase management is pharmacologic. Long-term measures should begin with conservative (nondestructive) measures with "adjuvant" measures (eg, vestibular rehabilitation) as necessary. Low vertigo severity, low comorbidity burden, and absence of hearing loss are factors associated with a conservative treatment response in Meniere's disease (155). Destructive measures are used if other approaches are unsuccessful.
Medical management. Current medical management can control vertiginous attacks in approximately 75% to 80% of patients but does not appear to alter the long-term progression of hearing loss (02). Initial management of Meniere syndrome involves diagnosing and treating the primary disease (eg, thyroid disease). Chronic management of Meniere disease should include therapeutic counseling, the use of hearing aids and masking devices, lifestyle modification, salt restriction, and diuretic therapy (62). A diary of vertigo attacks with symptoms during the episodes should be encouraged to improve phenotyping (62).
The use of hearing aids can help with hearing impairment and, in many cases, benefits the subjective tinnitus that accompanies the disorder. Masking devices are also helpful for the management of subjective tinnitus.
The major focus of lifestyle modification is avoiding potential disease triggers, including stress, fatigue, high-salt foods (eg, pizza, processed meats, canned soups, smoked fish, potato chips, peanuts, nuts, beer, etc.), and other potential trigger substances (eg, caffeine, nicotine, alcohol, monosodium glutamate, carbohydrate-rich foods, and foods high in cholesterol and triglycerides).
In patients with Meniere syndrome or Meniere disease, vestibular sedatives (eg, meclizine, dimenhydrinate, prochlorperazine, promethazine, prochlorperazine, benzodiazepines), particularly those with anti-emetic or anxiolytic properties, and intravenous fluids may help decrease symptoms acutely during an attack. Although some authors advocate intratympanic or systemic dexamethasone treatment, no definite treatment effect has been demonstrated (100).
A low-sodium diet and diuretics are considered the mainstays of chronic treatment for Meniere disease (260; 79; 264), and sodium restriction has been a foundation of disease management since the 1930s (40; 264; 225). Evidence of their validity remains weak (40; 51; 225; 254). Clinical experience and expert consensus suggest that a 1.0- to 1.5-gram low-sodium diet and diuretics (eg, hydrochlorothiazide and triamterene) may help to decrease the fluid pressure or volume within the inner ear and decrease the frequency of attacks, although these measures do not help once an acute attack has developed. Vestibular complaints decrease with diuretic therapy, but diuretics have no significant effect on hearing or tinnitus (245; 40). Acetazolamide was recommended for many years, but most authors have become discouraged with its use, and it has not been shown to prevent long-term deterioration in hearing (32; 47; 202; 42). A meta-analysis of the utility of diuretics for Meniere disease identified three systematic reviews that collectively included 19 studies, of which four were randomized trials (207). The authors concluded that it is unclear whether diuretics lead to a symptomatic improvement of vertigo or an objective decrease in hearing loss in patients with Meniere disease.
A small randomized controlled trial (25 subjects in each arm) found that a low-sodium diet with adequate water intake improved the hearing and alleviated vertigo and tinnitus in subjects with Meniere disease (275).
A longitudinal treatment study using a historical control found that a daily intake of 35 ml of water per kilogram of body weight dramatically relieved vertigo and significantly improved hearing over a 2-year period, whereas in a historical control group, patients had some improvement in vertigo but generally had progressive hearing loss over a similar time period (166). The authors concluded that the “deliberate modulation of the intake of water may be the simplest and most cost-effective medical treatment for patients with Meniere disease” (166).
The use of corticosteroids is controversial and largely empiric (40). It may help improve vertigo but does not significantly improve hearing or tinnitus.
Preliminary work has suggested a potential role for betahistine in improving hearing function in Meniere disease (160; 221; 264; 135), but this will have to be substantiated with well-designed randomized controlled trials, which are presently lacking (54; 247; 248). An umbrella systematic review concluded that betahistine probably does not reduce Meniere disease symptoms when compared with placebo (248).
Cochrane reviews concluded that the evidence for lifestyle or dietary interventions and for systemic pharmacological interventions for Meniere disease is very uncertain (254; 257); few randomized controlled trials have compared these interventions to placebo or no treatment, and the evidence that is currently available from these studies is of low or very low certainty.
Intratympanic steroids. The evidence comparing intratympanic corticosteroids to placebo or no treatment is of low or very low certainty (255). Limited evidence, restricted to one trial, supports the effectiveness of intratympanic steroids for improving vertigo in patients with Meniere disease (193). In an open-label, uncontrolled trial, there was a strong correlation between hearing improvement and dexamethasone treatment (161). Despite the limited evidence, a systematic review suggested that to achieve both hearing preservation and vertigo control, intratympanic steroids plus high-dose betahistine may be superior to intratympanic gentamicin because of the risk of hearing loss with intratympanic gentamicin despite good control of vertigo (01). The utility of this therapy will have to be substantiated with well-designed randomized controlled trials (248).
A Cochrane review found that the evidence for intratympanic corticosteroids in the treatment of Meniere disease is uncertain because of the relatively few published randomized trials and the concerns about publication bias in this area, given the identification of two large randomized trials that remain unpublished (255).
Ablative aminoglycoside therapies. Ablative therapy is a second-line management approach for failures of medical therapy. Among the various forms of ablative therapy, the most common are intratympanic aminoglycoside administration and vestibular neurectomy (02). Limited evidence from a single trial supports the effectiveness of intratympanic steroids for improving vertigo in patients with Meniere disease (193). The utility of this therapy will have to be substantiated with well-designed randomized controlled trials (248).
Oral aminoglycosides were used historically to treat Meniere syndrome and Meniere disease, but the resulting bilateral vestibular hypofunction was (and remains) extremely debilitating. Schuknecht described middle-ear perfusion with aminoglycosides for treatment of Meniere disease in the late 1950s (215), but transtympanic administration of aminoglycosides did not become popular as a treatment for Meniere disease until the late 1990s, providing an alternative to the disabling bilateral vestibular effects of systemic administration of aminoglycosides. Low-dose intratympanic application of gentamicin can provide a graduated destruction of sensory and epithelial cells in the cochlea in association with the generation of reactive oxygen species and reactive nitrogen species, including oxidation product of nitric oxide in the lateral wall and the organ of Corti (98; 167). Aminoglycosides are now generally applied unilaterally within the middle ear cavity, where they are absorbed into the inner ear through the round window membrane. Various methods of delivering medication to the middle ear have been employed, including injection through tympanostomy tubes or catheters through the tympanic membrane, needle injections through the tympanic membrane, and less commonly with a Eustachian tube catheter (29). No particular combination of method of administration, single versus multiple dosing, or concentration of aminoglycoside injected has yet been established as the most effective (29).
Transtympanic administration of aminoglycosides generally carries relatively low risks, has minimal systemic effects, and can be performed in patients whose comorbidities would preclude surgery (208; 41). Gentamicin is the aminoglycoside most frequently used for this purpose in the United States. Intratympanic gentamicin appears to be an effective treatment for vertigo in patients with Meniere disease but carries a risk of hearing loss (194). Studies indicate approximately 90% to 95% efficacy (complete elimination of vertigo in approximately 80% to 85% and more than 50% reduction in frequency in 10% to 15%), with clinically significant (ie, 10 dB or greater decrement in pure-tone average) worsening of hearing in the treated ear in 10% to 30% of patients (46; 10; 195; 29; 101; 112; 20; 56; 41). Extreme worsening (ie, 30 dB or greater decrement in pure-tone average) of hearing in the treated ear is rare (10; 41), and a significant fraction of treated ears (as much as a quarter in some studies) have a significant improvement in hearing (10). However, many of the available studies were poorly designed, and further controlled studies are needed (41).
Patients selected for transtympanic administration of aminoglycosides should be carefully selected and should generally undergo titrated therapy with low-dose gentamicin (41). Transtympanic gentamicin should be used cautiously: given that approximately 20% of patients ultimately develop bilateral disease, there is a significant risk of developing bilateral vestibular hypofunction, either from the disease itself or from the treatment, with incapacitating and irreversible disequilibrium and oscillopsia (40). Titration methods or multiple daily injections may be used in patients with profound or nonserviceable hearing (268). Treatment protocols with an injection interval of a week or more or those with “as needed” monthly injections provide the same level of vertigo control with better hearing preservation and should be used in patients with serviceable hearing (268). Vestibular-evoked myogenic potentials and the head thrust test are more reliable than other vestibular tests for the follow-up of patients undergoing gentamicin treatment (268).
A systematic review showed some benefit of intratympanic gentamicin over intratympanic corticosteroids for subjective outcomes but no difference regarding objective outcomes or complication rate (267).
Low-dose intratympanic gentamicin administration based on clinical symptomatology can produce satisfactory control of vertigo attacks while avoiding cochlear damage (214).
A Cochrane review concluded that the evidence for the use of intratympanic gentamicin in the treatment of Meniere disease is very uncertain because there are few published randomized trials, and all these enrolled a very small number of participants (256); because the studies assessed different outcomes, using different methods, and reported at different time points, pooling the results to obtain more reliable estimates of the efficacy of this treatment was not possible.
Surgical treatment. Surgical treatment of Meniere syndrome and Meniere disease is reserved for medical treatment failures but remains controversial (79; 02). The goal of surgery is to control episodic vertigo while maintaining preoperative hearing levels, though practically, surgical treatment typically has a severe impact on hearing function (144). Destructive procedures are generally reserved for severe cases, with associated significant disability, but are contraindicated with bilateral disease (which variously is reported to occur in from 7% to 50% of cases). Provided the contralateral vestibular apparatus functions adequately, the brain eventually compensates for the loss of a single labyrinth.
A Cochrane review was unable to draw clear conclusions about the efficacy of surgical interventions for Meniere disease because limited evidence was identified, and all of it was of low or very low certainty (123).
Endolymphatic sac decompression with or without shunt is thought to decrease endolymph pressure by removing the petrous bone overlying the sac; a drainage tube from the sac to either the mastoid space or subarachnoid space can be inserted to further reduce endolymph pressure. The success of endolymphatic sac decompression in controlling vertigo and stabilizing hearing has been reported at between 60% to 94% and 80% to 88%, regardless of whether a shunt is also performed (260; 23). Additionally, endolymphatic sac decompression is associated with a significantly improved perception of health in patients (60), and it has been reported that this may decrease the incidence of developing Meniere disease in contralateral ears with silent endolymphatic hydrops within the first 5 postoperative years (117). The procedure does not directly destroy or damage hearing or balance organs or pathways, and it can usually be done as an outpatient procedure (260). However, even retrospective comparative studies have suggested that endolymphatic sac decompression does not alter the long-term natural course of vertigo (227), and a critical Danish randomized, double-blind study that included a sham surgical procedure found that endolymphatic sac decompression was no more effective than sham surgery (240). Furthermore, the procedure is associated with worsened hearing in about one third of cases, and about one quarter subsequently have another secondary treatment after endolymphatic sac decompression (102). A systematic review of endolymphatic sac surgery for Meniere disease concluded that "there is still a lack of high-quality research, suggesting that endolymphatic sac surgery provides a significant amount of symptomatic relief for Meniere patients" (55); a subsequent systematic review came to the same conclusion (248). Nevertheless, the procedure remains popular among otolaryngologists (231), and some have concluded, based on longitudinal follow-up of a case series, that endolymphatic shunt surgery provides successful vertigo control at least as well as intratympanic gentamicin injections, with a lower incidence of audiovestibular complications (75).
For patients with useful hearing in the affected ear (ie, better than 80 dB pure-tone average and 20% speech discrimination) and who have failed other treatments, vestibular neurectomy through a retrosigmoid or middle fossa approach has a high rate of vertigo control (over 95%) with a high rate of hearing preservation (approximately 90% to 95%) (180; 208). Adverse outcomes are uncommon but may include facial nerve damage, hearing loss, exacerbation of tinnitus or dizziness, CSF leakage, meningitis, and hemorrhage. A minimally invasive vestibular neurotomy has been advocated as a safe and effective surgical treatment for these individuals, with reported benefits including improved dizziness and anxiety (156).
Labyrinthectomy also has a high rate of vertigo control (over 95%) and is useful for patients with unilateral disease whose hearing on the affected side has already been destroyed by the disease process (212; 128). This procedure is less invasive than vestibular nerve section and is accomplished using either a transcanal approach (cochleovestibular neurectomy) through the external ear canal or a transmastoid approach with extension of a mastoidectomy by drilling through the semicircular canals. Compared to vestibular nerve section, risk of CSF leakage or meningitis is lower because craniotomy is not required. Patients affected by end-stage Meniere disease with vertigo and severe hearing loss can successfully undergo labyrinthectomy and cochlear implantation, although in elderly patients, there is a significant risk of persistent instability (235).
Triple semicircular canal occlusion is an emerging surgical technique that holds promise as a partially ablative procedure with a high vertigo control rate in Meniere's disease (145). Triple semicircular canal occlusion has a high rate of vertigo control (97% in one retrospective study of 90 cases) with a high rate of preserved hearing (77% in the same retrospective study) (131). Combined triple semicircular canal occlusion and cochlear implantation is a viable treatment option that is effective for vertigo control and for restoring hearing in patients with Meniere disease (272).
Management of otolithic crises. Some authorities advocate conservative management of otolithic crises, particularly given that many cases have a flurry of episodes followed by remission (Janzen and Russel 1988; 13). However, the events can be associated with significant injuries, and for some patients, the attacks are so dangerous or intractable that surgery is indicated (13). Otolithic crises have been treated successfully with either surgical ablation (labyrinthectomy) or trans-tympanic gentamicin therapy in the absence of serviceable hearing, or middle fossa vestibular nerve section to preserve serviceable hearing (28; 169; 107; 251). Even older patients can be successfully treated with ablative surgery with excellent compensation and no vertigo or falls up to 10 years after surgery (107). Vestibular nerve section is usually recommended only for patients who have had symptoms for at least 5 years unless the patient is severely incapacitated or is in danger of severe bodily harm because of otolithic crises (28). Intratympanic gentamicin treatment appears to be a long-lasting and effective treatment for vestibular drop attacks in patients with Meniere disease (251).
Positive-pressure therapy. Because patients with Meniere disease have symptoms that can fluctuate with ambient air pressure, in the late 1980s, Densert and colleagues evaluated the utility of positive-pressure pulses applied to the middle ear and demonstrated that such pulses improved electrocochleographic parameters in these patients (40). Since then, portable low-amplitude, alternating-pressure generators (eg, the Meniett device from Medtronic Xomed, Inc.) have been developed to be worn in the external auditory canal and have been shown to be efficacious and safe in patients with Meniere disease (73; 40; 134). The device requires the placement of a long-term tympanostomy tube. Most patients note gradual improvement in vertigo when using the Meniett device; consequently, this device had been considered a useful option for patients with Meniere disease who had failed medical treatment (40). However, hearing does not improve with use of the device, and the device is expensive and rarely covered by insurers. Moreover, a randomized, double-blind, placebo-controlled, multicenter trial found no difference between the portable Meniett low-pressure pulse generator (Medtronic Xomed, Jacksonville, FL) and the placebo device groups in the treatment of Meniere disease (210).
A Cochrane review concluded that the evidence for positive pressure therapy for Meniere disease is very uncertain (258); few randomized controlled trials have compared this intervention to placebo or no treatment, and the evidence that is currently available from these studies is of low or very low certainty. A separate umbrella systematic review concluded that positive pressure therapy probably does not reduce Meniere disease symptoms when compared with placebo (248).
Cochlear implantation. Cochlear implantation in advanced Meniere disease is a valid option that can partially restore hearing, regardless of the disease duration, uni- or bilaterality, age at implantation, previous therapeutic procedures, and stage of activity of Meniere disease (24; 118; 151; 253; 111). It is helpful in improving hearing ability and suppressing tinnitus (253). Although cochlear implantation and labyrinthectomy in adult patients with Meniere disease can improve speech recognition and sound source localization for some patients, observed performance may be poorer than with traditional cochlear implantation candidates (219; 37).
Vestibular rehabilitation. Vestibular rehabilitation is generally recommended after aminoglycoside treatment or surgery and may be helpful in minimizing disability, particularly in older individuals (164; 40; 135; 204). However, available studies had a high risk of bias, and none had long-term follow-ups. Therefore, further studies are required to establish the efficacy of vestibular rehabilitation in Meniere disease, whether managed medically or surgically (204).
Certain tasks requiring balance and having a high risk of injury with falls (eg, climbing ladders) should generally be avoided.
Media
References
- 01
- Ahmadzai N, Cheng W, Kilty S, et al. Pharmacologic and surgical therapies for patients with Meniere's disease: a systematic review and network meta-analysis. PLoS One 2020;15(9):e0237523. PMID 32870918
- 02
- Albera R, Canale A, Parandero F, Ducati A, Lanotte M. Surgical indication in Menière's disease therapy: clinical and epidemiological aspects. Eur Arch Otorhinolaryngol 2011;268(7):967-72. PMID 21246208
- 03
- Alexander TH, Harris JP. Current epidemiology of Meniere's syndrome. Otolaryngol Clin North Am 2010;43(5):965-70. PMID 20713236
- 04
- Angelborg C, Klockhoff I, Stahle J. The caloric response in Meniere’s disease during spontaneous and glycerine-induced changes in hearing loss. Acta Otolaryngol 1971;71(6):462-8. PMID 5561984
- 05
- Anonymous. Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere's disease. American Academy of Otolaryngology-Head and Neck Foundation, Inc. Otolaryngol Head Neck Surg 1995;113(3):181-5.** PMID 7675476
- 06
- Arenberg IK. A clinical analysis of prosper Meniere’s original cases. Am J Otol 1989;10(4):314-26. PMID 2679117
- 07
- Arweiler-Harbeck D, Horsthemke B, Jahnke K, Hennies HC. Genetic aspects of familial Ménière's disease. Otol Neurotol 2011;32(4):695-700. PMID 21436747
- 08
- Atkinson M. Meniere’s famous autopsy and its interpretation. Arch Otolaryngol 1945;41:186-7.
- 09
- Atkinson M. Meniere’s original papers: reprinted with an English translation together with commentaries and biographical sketch. Acta Otolaryngol Suppl 1960;162:1-78.
- 10
- Atlas JT, Parnes LS. Intratympanic gentamicin titration therapy for intractable Meniere’s disease. Am J Otol 1999;20(3):357-63. PMID 10337978
- 11
- Attye A, Barma M, Schmerber S, Dumas G, Eliezer M, Krainik A. The vestibular aqueduct sign: magnetic resonance imaging can detect abnormalities in both ears of patients with unilateral Meniere's disease. J Neuroradiol 2020;47(2):174-9. PMID 30423380
- 12
- Attye A, Eliezer M, Galloux A, et al. Endolymphatic hydrops imaging: differential diagnosis in patients with Meniere disease symptoms. Diagn Interv Imaging 2017;98(10):699-706. PMID 28645678
- 13
- Baloh RW, Jacobsen K, Winder T. Drop attacks with Ménière’s disease. Ann Neurol 1990;28:384-7. PMID 2241120
- 14
- Bance M, Mai M, Tomlinson D, Rutka J. The changing direction of nystagmus in acute Menière's disease: pathophysiological implications. Laryngoscope 1991;101(2):197-201.** PMID 1992273
- 15
- Barath K, Schuknecht B, Naldi AM, Schrepfer T, Bockisch CJ, Hegemann SC. Detection and grading of endolymphatic hydrops in Menière disease using MR imaging. AJNR Am J Neuroradiol 2014;35(7):1387-92.** PMID 24524921
- 16
- Barlet J, Vaussy A, Ejzenberg Y, et al. Optimized 3D-FLAIR sequences to shorten the delay between intravenous administration of gadolinium and MRI acquisition in patients with Menière's disease. Eur Radiol 2022;32(10):6900-9. PMID 35759015
- 17
- Barrette LX, Xu K, Suresh N, et al. A systematic quality appraisal of clinical practice guidelines for Ménière's disease using the AGREE II instrument. Eur Arch Otorhinolaryngol 2022;279(7):3439-47. PMID 34657983
- 18
- Basura GJ, Adams ME, Monfared A, et al. Clinical Practice Guideline: Ménière's disease executive summary. Otolaryngol Head Neck Surg 2020a;162(4):415-34.** PMID 32267820
- 19
- Basura GJ, Adams ME, Monfared A, et al. Clinical Practice Guideline: Ménière's disease. Otolaryngol Head Neck Surg 2020b;162(2_suppl):S1-S55.** PMID 32267799
- 20
- Bauer PW, MacDonald CB, Cox LC. Intratympanic gentamicin therapy for vertigo in nonserviceable ears. Am J Otolaryngol 2001;22:111-5. PMID 11283825
- 21
- Beasley NJ, Jones NS. Meniere’s disease: evolution of a definition. J Laryngol Otol 1996;110(12):1107-13. PMID 9015421
- 22
- Belinchon A, Perez-Garrigues H, Tenias JM, Lopez A. Hearing assessment in Menière's disease. Laryngoscope 2011;121(3):622-6. PMID 21305548
- 23
- Bento RF, Cisneros JC, De Oliveira Fonseca AC. Endolymphatic sac drainage for the treatment of Ménière's disease. J Laryngol Otol 2017;131(2):144-49. PMID 27974068
- 24
- Berardino FD, Conte G, Turati F, Ferraroni M, Zanetti D. Cochlear implantation in Ménière's disease: a systematic review of literature and pooled analysis. Int J Audiol 2020;59(6):406-15. PMID 32027195
- 25
- Bernaerts A, De Foer B. Imaging of Ménière disease. Neuroimaging Clin N Am 2019;29(1):19-28. PMID 30466641
- 26
- Bernaerts A, Vanspauwen R, Blaivie C, et al. The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Menière's disease on MRI. Neuroradiology 2019;61(4):421-9.** PMID 30466641
- 27
- Bery AK, Chang TP. Teaching video neuroimages: spontaneous nystagmus reversal in acute attack of Ménière disease. Neurology 2021;96(16):e2145-6.** PMID 33055269
- 28
- Black FO, Effron MZ, Burns DS. Diagnosis and management of drop attacks of vestibular origin: Tumarkin’s otolithic crisis. Otolaryngol Head Neck Surg 1982;90(2):256-62. PMID 6810273
- 29
- Blakely BW. Update on intratympanic gentamicin for Meniere’s disease. Laryngoscope 2000;110:236-40. PMID 10680922
- 30
- Blodow A, Heinze M, Bloching MB, von Brevern M, Radtke A, Lempert T. Caloric stimulation and video-head impulse testing in Ménière's disease and vestibular migraine. Acta Otolaryngol 2014;134(12):1239-44. PMID 25399882
- 31
- Brenner M, Hoistad DL, Hain TC. Prevalence of thyroid dysfunction in patients with Ménière’s disease. Arch Otolaryngol Head Neck Surg 2004;130:226-8. PMID 14967756
- 32
- Brookes GB, Booth JB. Oral acetazolamide in Meniere’s disease. J Laryngol Otol 1984;98:1087-95. PMID 6491498
- 33
- Brown DH, McClure JA, Downar-Zapolski Z. The membrane rupture theory of Meniere’s disease--is it valid. Laryngoscope 1988;98(6 Pt 1):599-601. PMID 3374233
- 34
- Charcot JM. Ménière’s vertigo = vertigo ab aure læsa. In: Lectures on the diseases of the nervous system. Translated and edited by George Sigerson. London: New Sydenham Society, 1881:261-74.
- 35
- Chaves AG, Borai L, Lei Munhoz MS. The outcome of patients with Ménière’s disease. Rev Bras Otorrhinolaringol 2007;73:346-50. PMID 17684655
- 36
- Chen W, Xiao H, Zhang Y, Wang L, Li B, Sha Y. A 3-hour time interval may not be sufficient for delayed enhancement magnetic resonance imaging with intravenous gadoteridol injection based on 3d-real IR sequence of the inner ear in Meniere's disease patient. Acta Otolaryngol 2024;144(1):1-6. PMID 38315462
- 37
- Chien CY, Kulthaveesup A, Herrmann BS, Rauch SD. Cochlear implantation hearing outcome in Ménière's disease. Otolaryngol Head Neck Surg 2022;166(3):523-9. PMID 34003698
- 38
- Christopher LH, Wilkinson EP. Meniere's disease: medical management, rationale for vestibular preservation and suggested protocol in medical failure. Am J Otolaryngol 2021;42(1):102817. PMID 33202330
- 39
- Ciorba A, Skarżyński PH, Corazzi V, Bianchini C, Aimoni C, Hatzopoulos S. Assessment tools for use in patients with Ménière disease: an update. Med Sci Monit 2017;23:6144-9. PMID 29282350
- 40
- Coelho DH, Lalwani AK. Medical management of Ménière’s disease. Laryngoscope 2008;118(6):1099-108. PMID 18418279
- 41
- Cohen-Kerem R, Kisilevsky V, Einarson TR, et al. Intratympanic gentamicin for Menière’s disease: a meta-analysis. Laryngoscope 2004;114:2085-91. PMID 15564826
- 42
- Colletti V. Medical treatment in Meniere’s disease: avoiding vestibular neurectomy and facilitating postoperative compensation. Acta Otolaryngol Suppl 2000;544:27-33. PMID 10904798
- 43
- Conlon BJ, Gibson WP. Meniere’s disease: the incidence of hydrops in the contralateral asymptomatic ear. Laryngoscope 1999;109:1800-2. PMID 10569410
- 44
- Connor S, Grzeda MT, Jamshidi B, Ourselin S, Hajnal JV, Pai I. Delayed post gadolinium MRI descriptors for Meniere's disease: a systematic review and meta-analysis. Eur Radiol 2023;33(10):7113-35. PMID 37171493
- 45
- Conte G, Caschera L, Calloni S, et al. MR imaging in Menière disease: is the contact between the vestibular endolymphatic space and the oval window a reliable biomarker? AJNR Am J Neuroradiol 2018;39(11):2114-9. PMID 30337432
- 46
- Corsten M, Marsan J, Schramm D, Robichaud J. Treatment of intractable Meniere’s disease with intratympanic gentamicin: review of the University of Ottawa experience. J Otolaryngol 1997;26:361-4. PMID 9438932
- 47
- Corvera J, Corvera G. Long-term effect of acetazolamide and chlorthalidone on the hearing loss of Meniere’s disease. Am J Otol 1989;10:142-5. PMID 2735386
- 48
- Dai Q, Long L, Zhao H, Wang R, Zheng H, Duan M. Genetic advances in Meniere Disease. Mol Biol Rep 2023;50(3):2901-8. PMID 36565421
- 49
- Dandy WE. Ménière’s disease: its diagnosis and a method of treatment. Arch Surg 1928;16:1127-52.
- 50
- Dean NJ, Pastras C, Brown D, Camp A. Are viral-infections associated with Ménière's Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD. PLoS One 2019;14(11):e0225650. PMID 31756230
- 51
- De Luca P, Cassandro C, Ralli M, et al. Dietary restriction for the treatment of Meniere's disease. Transl Med UniSa 2020;22:5-9. PMID 32523900
- 52
- Deng W, Lin X, Su Y, Cai Y, Zhong J, Ou Y. Comparison between 3D-FLAIR and 3D-real IR MRI sequences with visual classification method in the imaging of endolymphatic hydrops in Meniere's disease. Am J Otolaryngol 2022;43(6):103557. PMID 35994892
- 53
- Derebery MJ. Allergic and immunologic features of Ménière's disease. Otolaryngol Clin North Am 2011;44(3):655-66, ix. PMID 21621052
- 54
- Devantier L, Hougaard D, Händel MN, et al. Using betahistine in the treatment of patients with Menière's disease: a meta-analysis with the current randomized-controlled evidence. Acta Otolaryngol 2020;140(10):845-53. PMID 32580600
- 55
- Devantier L, Schmidt JH, Djurhuus BD, et al. Current state of evidence for endolymphatic sac surgery in Menière's disease: a systematic review. Acta Otolaryngol 2019;139(11):953-8. PMID 31498014
- 56
- De Waele C, Meguenni R, Freyss G et al. Intratympanic gentamicin injections for Meniere’s disease: vestibular hair cell impairment and regeneration. Neurology 2002;59(9):1442-4. PMID 12427902
- 57
- DiBiase P, Arriaga MA. Post-traumatic hydrops. Otolaryngol Clin N Am 1997;30:1117-22. PMID 9386247
- 58
- Dimitri PS, Wall C 3rd, Oas JS, Rauch SD. Application of multivariate statistics to vestibular testing: discriminating between Meniere’s disease and migraine associated dizziness. J Vestib Res 2001;11(1):53-65. PMID 11673678
- 59
- Dohlman GF. Further remarks on the mechanism producing the symptoms of Meniere’s disease. J Otolaryngol 1980;9:285-90. PMID 7420519
- 60
- Durland WF Jr, Pyle M, Connor NP. Endolymphatic sac decompression as a treatment for Meniere’s disease. Laryngoscope 2005;115:1454-7. PMID 16094123
- 61
- Escalera-Balsera A, Parra-Perez AM, Gallego-Martinez A, et al. Rare deletions or large duplications contribute to genetic variation in patients with severe tinnitus and Meniere disease. Genes (Basel) 2023;15(1):22. PMID 38254912
- 62
- Espinosa-Sanchez JM, Lopez-Escamez JA. The pharmacological management of vertigo in Meniere disease. Expert Opin Pharmacother 2020;21(14):1753-63. PMID 32539493
- 63
- Fife TD, Colebatch JG, Kerber KA, et al. Practice guideline: cervical and ocular vestibular evoked myogenic potential testing: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology 2017;89(22):2288-96. PMID 29093067
- 64
- Filipo R, Ciciarello F, Attanasio G, et al. Chronic cerebrospinal venous insufficiency in patients with Ménière's disease. Eur Arch Otorhinolaryngol 2015;272(1):77-82. PMID 24318422
- 65
- Fiorino F, Pizzini FB, Beltramello A, Barbieri F. Progression of endolymphatic hydrops in Ménière's disease as evaluated by magnetic resonance imaging. Otol Neurotol 2011a;32(7):1152-7. PMID 21817938
- 66
- Fiorino F, Pizzini FB, Beltramello A, Mattellini B, Barbieri F. Reliability of magnetic resonance imaging performed after intratympanic administration of gadolinium in the identification of endolymphatic hydrops in patients with Ménière's disease. Otol Neurotol 2011b;32(3):472-7. PMID 21307806
- 67
- Frejo L, Lopez-Escamez JA. Recent advances in understanding molecular bases of Ménière's disease. Fac Rev 2023;12:11. PMID 37284494
- 68
- Frejo L, Martin-Sanz E, Teggi R, et al. Extended phenotype and clinical subgroups in unilateral Meniere disease: a cross-sectional study with cluster analysis. Clin Otolaryngol 2017;42(6):1172-80. PMID 28166395
- 69
- Frejo L, Soto-Varela A, Santos-Perez S, et al. Clinical subgroups in bilateral Meniere disease. Front Neurol 2016;7:182. PMID 27822199
- 70
- Friberg U, Stahle J, Svedberg A. The natural course of Meniere’s disease. Acta Otolaryngol Suppl 1984;406:72-7. PMID 6591717
- 71
- Fukushima M, Kadowaki S, Nakatani S, Waki S, Matsumoto K, Okamoto H. Impact of endolymphatic hydrops on the function of the horizontal canal during caloric stimulation in Ménière's disease. Eur Arch Otorhinolaryngol 2024;281(4):1701-8. PMID 37804352
- 72
- Gacek RR, Gacek MR. Menière’s disease as a manifestation of vestibular ganglionitis. Am J Otolaryngol 2001;22:241-50. PMID 11464320
- 73
- Gates GA, Verrall A, Green JD Jr, Tucci DL, Telian SA. Meniett clinical trial: long-term follow-up. Arch Otolaryngol Head Neck Surg 2006;132(12):1311-6. PMID 17178941
- 74
- Gazquez I, Soto-Varela A, Aran I, Santos S, et al. High prevalence of systemic autoimmune diseases in patients with Ménière's disease. PLoS One 2011;6(10):e26759. PMID 22053211
- 75
- Gibson AW, Moon IJ, Golub JS, Rubinstein JT. A comparison of endolymphatic shunt surgery and intratympanic gentamicin for Meniere's disease. Laryngoscope 2020;130(10):2455-60. PMID 31808957
- 76
- Gluth MB. On the relationship between Menière's disease and endolymphatic hydrops. Otol Neurotol 2020;41(2):242-9. PMID 31746815
- 77
- Goebel JA. 2015 Equilibrium Committee Amendment to the 1995 AAO-HNS guidelines for the definition of Ménière's Disease. Otolaryngol Head Neck Surg 2016;154(3):403-4. PMID 26884364
- 78
- Gopen Q, Viirre E, Anderson J. Epidemiologic study to explore links between Ménière syndrome and migraine headache. Ear Nose Throat J 2009;88(11):1200-4. PMID 19924661
- 79
- Greenberg SL, Nedzelski JM. Medical and noninvasive therapy for Meniere's disease. Otolaryngol Clin North Am 2010;43(5):1081-90. PMID 20713246
- 80
- Gros JC. The history of Meniere’s disease. J Tenn Med Assoc 1967;60:520-3. PMID 4859844
- 81
- Gulya AJ, Schuknecht HF. Classification of endolymphatic hydrops. Am J Otolaryngol 1982;3:319-22. PMID 7149144
- 82
- Gundrum LK. Post-traumatic Meniere’s symptom-complex. Ear Nose Throat J 1959;38(5):385-8. PMID 13639969
- 83
- Gurkov R. Menière and friends: imaging and classification of hydropic ear disease. Otol Neurotol 2017;38(10):e539-44. PMID 29135874
- 84
- Gurkov R, Flatz W, Louza J, Strupp M, Krause E. In vivo visualization of endolyphatic hydrops in patients with Meniere's disease: correlation with audiovestibular function. Eur Arch Otorhinolaryngol 2011;268(12):1743-8. PMID 21431434
- 85
- Gurkov R, Hornibrook J. On the classification of hydropic ear disease (Menière's disease). HNO 2018;66(6):455-63. PMID 29500497
- 86
- Gurkov R, Pyykö I, Zou J, Kentala E. What is Menière's disease? A contemporary re-evaluation of endolymphatic hydrops. J Neurol 2016;263 Suppl 1:71-81. PMID 27083887
- 87
- Gurkov R, Todt I, Jadeed R, Sudhoff H, Gehl HB. Laterality of audiovestibular symptoms predicts laterality of endolymphatic hydrops in hydropic ear disease (Menière). Otol Neurotol 2020;41(9):e1140-4. PMID 32925855
- 88
- Hahn HJ, Kwak SG, Kim DK, Kim JY. A nationwide, population-based cohort study on potential autoimmune association of Ménière disease to atopy and vitiligo. Sci Rep 2019;9(1):4406. PMID 30867466
- 89
- Hallpike CS. The investigation of Ménière’s disease. J Laryngol Otol 1943;58:349-62.
- 90
- Hallpike CS, Cairns H. Observations on the pathology of Ménière’s syndrome. J Laryngol Otol 1938;53:625-55.
- 91
- Hallpike CS, Wright AJ. On the histological changes in the temporal bones of a case of Ménière’s disease. Proc Roy Soc Med 1939;32:1646-56. PMID 19992169
- 92
- Hallpike CS, Wright AJ. On the histological changes in the temporal bones of a case of Ménière’s disease. J Laryngol Otol 1940;55:59-66. PMID 19992169
- 93
- Han A, Kontorinis G. A systematic review on delayed acquisition of post-gadolinium magnetic resonance imaging in Ménière's disease: imaging of the endolymphatic spaces. J Laryngol Otol 2023;137(3):239-45. PMID 35674257
- 94
- Han Y, Zhang J, Lui L, et al. The diagnostic value of 1.5T versus 3.0T magnetic resonance imaging intratympanic gadolinium inner ear enhancement in patients with Meniere's disease. J Int Adv Otol 2022;18(5):388-91. PMID 36063094
- 95
- Hannigan IP, Rosengren SM, Young AS, et al. A portrait of Menière's disease using contemporary hearing and balance tests. Otol Neurotol 2022;43(4):e489-96. PMID 35085109
- 96
- Hannigan IP, Welgampola MS, Watson SRD. Dissociation of caloric and head impulse tests: a marker of Meniere's disease. J Neurol 2021;268(2):431-9. PMID 31222419
- 97
- Havia M, Kentala E. Progression of symptoms of dizziness in Ménière’s disease. Arch Otolaryngol Head Neck Surg 2004;130:431-5. PMID 15096425
- 98
- Heinrich UR, Helling K, Sifferath M, et al. Gentamicin increases nitric oxide production and induces hearing loss in guinea pigs. Laryngoscope 2008;118(8):1438-42. PMID 18496154
- 99
- Hietikko E, Kotimäki J, Sorri M, Männikkö M. High incidence of Meniere-like symptoms in relatives of Meniere patients in the areas of Oulu University Hospital and Kainuu Central Hospital in Finland. Eur J Med Genet 2013;56(6):279-85. PMID 23542667
- 100
- Hirvonen TP, Peltomaa M, Ylikoski J. Intratympanic and systemic dexamethasone for Meniere’s disease. ORL J Otorhinolaryngol Relat Spec 2000;62(3):117-20. PMID 10810254
- 101
- Hone SW, Nedzelski J, Chen J. Does intratympanic gentamicin treatment for Meniere’s disease cause complete vestibular ablation. J Otolaryngol 2000;20:83-7. PMID 10819105
- 102
- Hu A, Parnes LS. 10-year review of endolymphatic sac surgery for intractable meniere disease. J Otolaryngol Head Neck Surg 2010;39(4):415-21. PMID 20643008
- 103
- Hu Y, Zhang Y, Zhao X, Li J. Endolymphatic hydrops imaging and correlation with clinical characteristics, audiovestibular function and mental impairment in patients with Meniere's disease. Eur Arch Otorhinolaryngol 2023;280(9):4027-36. PMID 36849561
- 104
- Huang Y, Zhao P, Han Z, et al. Evaluation of the relationship between endolymphatic hydrops and hearing loss in Meniere's disease based on three-dimensional real inversion recovery sequence. Braz J Otorhinolaryngol 2023;89(5):101314. PMID 37688911
- 105
- Hwang G, Saadi R, Patel VA, Liaw J, Isildak H. Thyroid dysfunction in Ménière's disease: a comprehensive review. ORL J Otorhinolaryngol Relat Spec 2021;83(4):219-26. PMID 33853078
- 106
- Ihler F, Stoycheva I, Spiegel JL, et al. Diagnosis of Menière's disease according to the criteria of 2015: characteristics and challenges in 96 patients. J Vestib Res 2022;32(3):271-83. PMID 34151878
- 107
- Ishiyama G, Ishiyama A, Jacobson K, Baloh RW. Drop attacks in older patients secondary to an otologic cause. Neurology 2001;57(6):1103-6. PMID 11571344
- 108
- Ito T, Inui H, Miyasaka T, Shiozaki T, et al. Endolymphatic volume in patients with Meniere's disease and healthy controls: three-dimensional analysis with magnetic resonance imaging. Laryngoscope Investig Otolaryngol 2019;4(6):653-8. PMID 31890884
- 109
- Janzen VD, Russell RD. Conservative management of Tumarkin's otolithic crisis. J Otolaryngol 1988;17(7):359-61. PMID 3230608
- 110
- Johns JD, Olszewski R, Strepay D, Lopez IA, Ishiyama A, Hoa M. Emerging mechanisms in the pathogenesis of Menière's disease: evidence for the involvement of ion homeostatic or blood-labyrinthine barrier dysfunction in human temporal bones. Otol Neurotol 2023;44(10):1057-65. PMID 37733989
- 111
- Kanona H, Forde C, Van Rooyen AM, et al. Cochlear implant outcomes in patients with Meniere's disease: a large case series. Cochlear Implants Int 2022;23(6):339-46. PMID 36050279
- 112
- Kaplan DM, Nedzelski JM, Chen JM, Shipp DB. Intratympanic gentamicin for the treatment of unilateral Meniere’s disease. Laryngoscope 2000;110:1298-305. PMID 10942130
- 113
- Kenis C, Crins T, Bernaerts A, Casselman J, Foer B. Diagnosis of Menière's disease on MRI: feasibility at 1.5 Tesla. Acta Radiol 2022;63(6):810-3. PMID 34000823
- 114
- Kim MH. Population-based study for the comorbidities and associated factors in Ménière's disease. Sci Rep 2022;12(1):8266. PMID 35585157
- 115
- Kim MH, Cheon C. Epidemiology and seasonal variation of Ménière's disease: data from a population-based study. Audiol Neurootol 2020;25(4):224-30. PMID 32289780
- 116
- Kim SY, Song YS, Wee JH, Min C, Yoo DM, Choi HG. Association between Ménière's disease and thyroid diseases: a nested case-control study. Sci Rep 2020;10(1):18224. PMID 33106572
- 117
- Kitahara T, Horii A, Imai T, et al. Does endolymphatic sac decompression surgery prevent bilateral development of unilateral Ménière disease? Laryngoscope 2014;124(8):1932-6. PMID 24464868
- 118
- Kocharyan A, Mark ME, Ascha MS, et al. Cochlear implantation in patients with Menière's disease: does disease activity affect the outcome? Otol Neurotol 2020;41(9):1296-304. PMID 32925864
- 119
- Kutlubaev MA, Xu Y, Hornibrook J. Benign paroxysmal positional vertigo in Meniere's disease: systematic review and meta-analysis of frequency and clinical characteristics. J Neurol 2021;268(5):1608-14. PMID 31410549
- 120
- Kutlubaev MA, Xu Y, Manchaiah V, Zou J, Pyykkö I. Vestibular drop attacks in Ménière's disease: a systematic review and meta-analysis of frequency, correlates and consequences. J Vestib Res 2022;32(2):171-82. PMID 33935127
- 121
- Lahiji MR, Akbarpour M, Soleimani R, et al. Prevalence of anxiety and depression in Meniere's disease; a comparative analytical study. Am J Otolaryngol 2022;43(5):103565. PMID 35981431
- 122
- Lamounier P, de Souza TSA, Gobbo DA, Bahmad F Jr. Evaluation of vestibular evoked myogenic potentials (VEMP) and electrocochleography for the diagnosis of Ménière's disease. Braz J Otorhinolaryngol 2017;83(4):394-403. PMID 27397722
- 123
- Lee A, Webster KE, George B, et al. Surgical interventions for Ménière's disease. Cochrane Database Syst Rev 2023;2(2):CD015249.** PMID 36825750
- 124
- Lee CS, Paprella MM, Margolis RH, Le C. Audiological profiles and Meniere’s disease. Ear Nose Throat J 1995;74:527-32. PMID 7555870
- 125
- Lee H, Yi HA, Lee SR, Ahn BH, Park BR. Drop attacks in elderly patients secondary to otologic causes with Meniere’s syndrome or non-Meniere peripheral vestibulopathy. J Neurol Sci 2005;232:71-6. PMID 15850585
- 126
- Lee SU, Kim HJ, Choi JY, Kim JS. Ictal downbeat nystagmus in Ménière disease: a cross-sectional study. Neurology 2020;95(17):e2409-17. PMID 32817190
- 127
- Lee SU, Kim HJ, Choi JY, Koo JW, Kim JS. Evolution of caloric responses during and between the attacks of Meniere's disease. J Neurol 2021;268(8):2913-21. PMID 33611629
- 128
- Leonard V, Garin P, Gilain C, Saerens M, Van Damme JP. Surgical labyrinthectomy in the treatment of unilateral Meniere disease: a Belgian retrospective study. Eur Arch Otorhinolaryngol 2024;281(4):1753-9. PMID 37938372
- 129
- Li J, Wang L, Hu N, et al. Improving diagnostic accuracy for probable and definite Ménière's disease using magnetic resonance imaging. Neuroradiology 2023a;65(9):1371-9. PMID 37328652
- 130
- Li J, Li L, Jin X, et al. MRI can help differentiate Ménière's disease from other menieriform diseases. Sci Rep 2023b;13(1):21527. PMID 38057393
- 131
- Li X, Lyu Y, Li Y, et al. Triple semicircular canal plugging versus labyrinthectomy for Meniere disease: a retrospective study. Laryngoscope 2023c;133(11):3178-84. PMID 37036082
- 132
- Li X, Wu Q, Sha Y, Dai C, Zhang R. Gadolinium-enhanced MRI reveals dynamic development of endolymphatic hydrops in Ménière's disease. Braz J Otorhinolaryngol 2020;86(2):165-73. PMID 30600169
- 133
- Limviriyakul S, Luangsawang C, Suvansit K, Prakairungthong S, Thongyai K, Atipas S. Video head impulse test and caloric test in definite Ménière's disease. Eur Arch Otorhinolaryngol 2020;277(3):679-86. PMID 31749057
- 134
- Liu F, Huang W, Chen K. Clinical long-term effects of surgical treatment for intractable Meniere's disease: a more than 13-year follow-up after pressure treatment and further surgical treatment for intractable vertigo. Acta Otolaryngol 2019;139(12):1053-7. PMID 31556757
- 135
- Liu JL, Liu JG, Chen XB, Liu YH. The benefits of betahistine or vestibular rehabilitation (Tetrax biofeedback) on the quality of life and fall risk in patients with Ménière's disease. J Laryngol Otol 2020;134(12):1073-6. PMID 33280619
- 136
- Liu YF, Xu H. The intimate relationship between vestibular migraine and Meniere disease: a review of pathogenesis and presentation. Behav Neurol 2016;2016:3182735. PMID 27651559
- 137
- Lopez-Escamez JA, Attyé A. Systematic review of magnetic resonance imaging for diagnosis of Meniere disease. J Vestib Res 2019;29(2-3):121-9. PMID 31356219
- 138
- Lopez-Escamez JA, Batuecas-Caletrio A, Bisdorff A. Towards personalized medicine in Ménière's disease. F1000Res 2018;7. PMID 30430003
- 139
- Lopez-Escamez JA, Carey J, Chung WH, et al. Diagnostic criteria for Menière's disease. J Vestib Res 2015;25(1):1-7.** PMID 25882471
- 140
- Lopez-Escamez JA, Carey J, Chung WH, et al. Diagnostic criteria for Menière's disease. Consensus document of the Bárány Society, the Japan Society for Equilibrium Research, the European Academy of Otology and Neurotology (EAONO), the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) and the Korean Balance Society. Acta Otorrinolaringol Esp 2016;67(1):1-7. PMID 26277738
- 141
- Lopez-Escamez JA, Liu Y. Epidemiology and genetics of Meniere's disease. Curr Opin Neurol 2024;37(1):88-94. PMID 37865853
- 142
- Lopez-Escamez JA, Vela J, Frejo L. Immune-related disorders associated with Ménière's disease: a systematic review and meta-analysis. Otolaryngol Head Neck Surg 2023;169(5):1122-31. PMID 37272729
- 143
- Loureiro RM, Sumi DV, Lemos MD, et al. The role of magnetic resonance imaging in Ménière disease: the current state of endolymphatic hydrops evaluation. Einstein (Sao Paulo) 2019;17(1):eMD4743. PMID 30810586
- 144
- Luca P, Ralli M, Cassandro C, et al. Surgical management of intractable Meniere's disease. Int Tinnitus J 2022;26(1):50-6. PMID 35861458
- 145
- Lucas JC, Hong RS. Recent surgical advances and continued controversies in medically refractory Meniere's disease. Curr Opin Otolaryngol Head Neck Surg 2023;31(5):325-31. PMID 37266594
- 146
- Magnan J, Özgirgin ON, Trabalzini F, et al. European position statement on diagnosis, and treatment of Meniere's disease. J Int Adv Otol 2018;14(2):317-21. PMID 30256205
- 147
- Maheu M, Alvarado-Umanzor JM, Delcenserie A, Champoux F. The clinical utility of vestibular-evoked myogenic potentials in the diagnosis of Ménière's disease. Front Neurol 2017;8:415. PMID 28861037
- 148
- Maihoub S, Molnar A, Gáborján A, Tamás L, Szirmai Á. Comparative study between the auditory and vestibular functions in Ménière's disease. Ear Nose Throat J 2022;101(8):NP329-33. PMID 33124933
- 149
- Mammarella F, Zelli M, Varakliotis T, Eibenstein A, Pianura CM, Bellocchi G. Is electrocochleography still helpful in early diagnosis of Meniere disease? J Audiol Otol 2017;21(2):72-6. PMID 28704892
- 150
- Maranhao-Filho P, Maranhao ET, de Oliveira CM. Prosper Menière: the man who located vertigo in the inner ear. Arq Neuropsiquiatr 2021;79(3):254-6. PMID 33886800
- 151
- Masood MM, Farquhar DR, Brown KD, Pillsbury HC, King ER, O'Connell BP. Hearing preservation and speech outcomes after cochlear implantation in Meniere's disease. Laryngoscope 2020;130(12):2874-8. PMID 31821566
- 152
- Mateijsen DJ, Hengel PW, Kingma H, Oreel MA, Wit HP, Albers FW. Vertigo and electronystagmography in uni- and bilateral Ménière’s disease. ORL J Otorhinolaryngol Relat Spec 2001;63(6):341-8. PMID 11713422
- 153
- McClure JA, Copp JC, Lycett P. Recovery nystagmus in Ménière’s disease. Laryngoscope 1981;91(10):1727-37.** PMID 7289703
- 154
- McClure JA, Lycett P. Recovery nystagmus. J Otolaryngol 1978;7:141-8. PMID 206716
- 155
- Miller BJ, Kallogjeri D, Shew MA, Piccirillo JF. Identifying predictors of treatment response in Meniere's disease: a clinical severity staging system. Otolaryngol Head Neck Surg 2024;170(1):212-20. PMID 37622528
- 156
- Miyazaki H, Nomura Y, Mardassi A, et al. How minimally invasive vestibular neurotomy for incapacitating Meniere's disease improves dizziness and anxiety. Acta Otolaryngol 2017;137(7):707-11. PMID 28125309
- 157
- Mizukoshi K, Watanabe Y, Shojaku H, Matsunaga T, Tokumasu K. Preliminary guidelines for reporting treatment results in Meniere’s disease conducted by the Committee of the Japanese Society for Equilibrium Research, 1993. Acta Otolaryngol Suppl 1995;519:211-5. PMID 7610871
- 158
- M’Kenzie D. Meniere’s original case. J Laryngol Otol 1924;39:446-9.
- 159
- Mohseni-Dargah M, Falahati Z, Pastras C, et al. Meniere's disease: pathogenesis, treatments, and emerging approaches for an idiopathic bioenvironmental disorder. Environ Res 2023;238(Pt 1):116972. PMID 37648189
- 160
- Moller MN, Kirkeby S, Vikeså J, Nielsen FC, Caye-Thomasen P. Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease. Eur Arch Otorhinolaryngol 2016;273(7):1705-10. PMID 26208913
- 161
- Molnar A, Maihoub S, Tamás L, Szirmai Á. Intratympanically administered steroid for progressive sensorineural hearing loss in Ménière's disease. Acta Otolaryngol 2019;139(11):982-6. PMID 31498001
- 162
- Molnar A, Maihoub S, Tamás L, Szirmai Á. Comparison between caloric and video-head impulse tests in Ménière's disease and vestibular neuritis. Int J Audiol. 2023;62(5):393-399. PMID: 35439091
- 163
- Moshtaghi O, Sahyouni R, Lin HW, Ghavami Y, Djalilian HR. A historical recount: discovering Menière's disease and its association with migraine headaches. Otol Neurotol 2016;37(8):1199-203. PMID 27362737
- 164
- Mruzek M, Barin K, Nichols DS, Burnett CN, Welling DB. Effects of vestibular rehabilitation and social reinforcement on recovery following ablative surgery. Laryngoscope 1995;105:686-92. PMID 7603271
- 165
- Nadol JB Jr. Positive Hennebert's sign in Meniere's disease. Arch Otolaryngol 1977;103(9):524-30. PMID 901278
- 166
- Naganuma H, Kawahara K, Tokumasu K, Okamoto M. Water may cure patients with Meniere disease. Laryngoscope 2006;116(8):1455-60. PMID 16885753
- 167
- Naples JG, Henry L, Brant JA, Eliades SJ, Ruckenstein MJ. Intratympanic therapies in Ménière disease: evaluation of outcomes and early vertigo control. Laryngoscope 2019;129(1):216-21. PMID 30284276
- 168
- Nodar RH, Graham JT. An investigation of frequency characteristics of tinnitus associated with Meniere’s disease. Arch Otolaryngol 1965;82:28-31. PMID 14310173
- 169
- Odkvist LM, Bergenius J. Drop attacks in Meniere's disease. Acta Otolaryngol Suppl 1988;455:82-5. PMID 3265265
- 170
- Oliveira LNR, Oliveira CLA, Lopes KC, Ganança FF. Diagnostic assessment of patients with Meniere's disease through caloric testing and the video-head-impulse test. Braz J Otorhinolaryngol 2021;87(4):428-33. PMID 31870737
- 171
- Oosterveld WJ. Menière’s disease, signs and symptoms. J Laryngol Otol 1980;94:885-94. PMID 6968803
- 172
- Pai I, Connor S. Low frequency air-bone gap in Meniere's disease: relationship with magnetic resonance imaging features of endolymphatic hydrops. Ear Hear 2022;43(6):1678-86. PMID 35583512
- 173
- Pai I, Mendis S, Murdin L, Touska P, Connor S. Magnetic resonance imaging of Ménière's disease: early clinical experience in a UK centre. J Laryngol Otol 2020;134(4):302-10. PMID 32241307
- 174
- Pakdaman MN, Ishiyama G, Ishiyama A, et al. Blood-labyrinth barrier permeability in Menière disease and idiopathic sudden sensorineural hearing loss: findings on delayed postcontrast 3D-FLAIR MRI. AJNR Am J Neuroradiol 2016;37(10):1903-8. PMID 27256854
- 175
- Paparella MM. The cause (multifactorial inheritance) and pathogenesis (endolymphatic malabsorption) of Meniere’s disease and its symptoms (mechanical and chemical). Acta Otolaryngol 1985;99:445-51. PMID 4013733
- 176
- Paparella MM. Pathogenesis and pathophysiology of Meniere’s disease. Acta Otolaryngol Suppl 1991;485:26-35. PMID 1843169
- 177
- Paparella MM, Mancini F. Trauma and Meniere’s syndrome. Laryngoscope 1983;93:1004-12. PMID 6877007
- 178
- Paparella MM, Morizono T, Matsunaga T. Kyoshiro Yamakawa, MD, and temporal bone histopathology of Meniere’s patient reported in 1938: commemoration of the centennial of his birth. Arch Otolaryngol Head Neck Surg 1992;118:660-2. PMID 1637546
- 179
- Pappas DG, Galanos AN. Prosper Menière: beyond the controversial autopsy report. South Med J 1982;75:470-2. PMID 7041283
- 180
- Pappas DG Jr, Pappas DG Sr. Vestibular nerve section: long-term follow-up. Laryngoscope 1997;107:1203-9. PMID 9292604
- 181
- Parnes LS, McClure JA. Rotary recovery nystagmus: an important localizing sign in endolymphatic hydrops. J Otolaryngol 1990;19:96-9. PMID 2348512
- 182
- Parra-Perez AM, Lopez-Escamez JA. Types of inheritance and genes associated with familial Meniere disease. J Assoc Res Otolaryngol 2023;24(3):269-79. PMID 37022572
- 183
- Parra-Perez AM, Gallego-Martinez A, Lopez-Escamez JA. An overload of missense variants in the OTOG gene may drive a higher prevalence of familial Meniere disease in the European population. Hum Genet 2024;143(3):423-35. PMID 38519595
- 184
- Paskoniene A, Baltagalvienė R, Lengvenis G, et al. The importance of the temporal bone 3T MR imaging in the diagnosis of Menière's disease. Otol Neurotol 2020;41(2):235-41. PMID 31743294
- 185
- Patel JJ, Levy DA, Nguyen SA, Rizk HG, Meyer TA. Depression in Ménière's disease: a systematic review and meta-analysis. J Laryngol Otol 2020;134(4):293-301. PMID 32301406
- 186
- Pender DJ. Membrane stress in the human labyrinth and Meniere disease: a model analysis. Int Arch Otorhinolaryngol 2015;19(4):336-42. PMID 26491481
- 187
- Perez R, Chen JM, Nedzelski JM. The status of the contralateral ear in established unilateral Menière’s disease. Laryngoscope 2004;114:1373-6. PMID 15280710
- 188
- Perez-Carbonell T, Orts-Alborch M, Pla-Gil I, et al. Bilateral Ménière's disease according to its form of debut: synchronous and metachronous disease. J Laryngol Otol 2023;137(7):782-8. PMID 36200516
- 189
- Perez-Fernandez N, Montes-Jovellar L, Cervera-Paz J, Domenech-Vadillo E. Auditory and vestibular assessment of patients with Ménière's disease who suffer Tumarkin attacks. Audiol Neurootol 2010;15(6):399-406. PMID 20389064
- 190
- Perez Garrigues H. Editorial commentary: "Diagnostic criteria for Menière's disease". Acta Otorrinolaringol Esp 2016;67(1):8. PMID 26708328
- 191
- Perez-Garrigues H, Lopez-Escamez JA, Perez P, et al. Time course of episodes of definitive vertigo in Ménière’s disease. Arch Otolaryngol Head Neck Surg 2008;134(11):1149-54. PMID 19015442
- 192
- Phillips J, Murdin L, Grant K, et al. Risk factors for the development of bilateral Ménière's disease. Otol Neurotol 2023;44(9):925-30. PMID 37590874
- 193
- Phillips JS, Westerberg B. Intratympanic steroids for Ménière's disease or syndrome. Cochrane Database Syst Rev 2011;(7):CD008514. PMID 25494154
- 194
- Pullens B, van Benthem PP. Intratympanic gentamicin for Ménière's disease or syndrome. Cochrane Database Syst Rev 2011;(3):CD008234. PMID 25494154
- 195
- Pyykko I, Eklund S, Ishizaki H, Aalto H. Postural compensation after intratympanic gentamicin treatment of Meniere’s disease. J Vestib Res 1999;9:19-26. PMID 10334013
- 196
- Pyykko I, Manchaiah V, Zou J, Levo H, Kentala E. Do patients with Ménière's disease have attacks of syncope? J Neurol 2017;264(Suppl 1):48-54. PMID 28321563
- 197
- Pyykko I, Manchaiah V, Zou J, Levo H, Kentala E. Impact of Tumarkin attacks on complaints and work ability in Ménière's disease. J Vestib Res 2018b;28(3-4):319-30. PMID 29843293
- 198
- Pyykko I, Manchaiah V, Zou J, Levo H, Kentala E. Vestibular syncope: a disorder associated with drop attack in Ménière's disease. Auris Nasus Larynx 2018a;45(2):234-41. PMID 28478076
- 199
- Pyykko I, Nakashima T, Yoshida T, Zou J, Naganawa S. Meniere's disease: a reappraisal supported by a variable latency of symptoms and the MRI visualisation of endolymphatic hydrops. BMJ Open 2013;3(2):e001555. PMID 23418296
- 200
- Pyykko I, Pyykkö N, Manchaiah V. Vestibular drop attacks in Ménière's disease and its association with migraine. Eur Arch Otorhinolaryngol 2020;277(7):1907-16. PMID 32185501
- 201
- Radtke A, Lempert T, Gresty MA, Brookes GB, Bronstein AM, Neuhauser H. Migraine and Ménière’s disease: is there a link. Neurology 2002;59:1700-4. PMID 12473755
- 202
- Ralli G, Celestino D, Fabbricatore M, Gabini S, Taverniti L. [Effect of acetazolamide on Meniere’s disease]. Acta Otorhinolaryngol Ital 1989;9:503-9. PMID 2626955
- 203
- Rauch SD, Merchant SN, Thedinger BA. Meniere’s syndrome and endolymphatic hydrops: double-blind temporal bone study. Ann Otol Rhinol Laryngol 1989;98:873-83. PMID 2817679
- 204
- Rezaeian A, Abtahi H, Moradi M, Farajzadegan Z. The effect of vestibular rehabilitation in Meniere's disease: a systematic review and meta-analysis of clinical trials. Eur Arch Otorhinolaryngol 2023;280(9):3967-75. PMID 37341761
- 205
- Rizvi SS. Investigations into the cause of canal paresis in Meniere’s disease. Laryngoscope 1986;96:1258-71. PMID 3773627
- 206
- Roman-Naranjo P, Gallego-Martinez A, Soto-Varela A, et al. Burden of rare variants in the OTOG gene in familial Meniere's disease. Ear Hear 2020;41(6):1598-605. PMID 32251013
- 207
- Rosenbaum A, Winter M. Are diuretics effective for Ménière`s disease? Medwave 2018;18(2):e7188. PMID 29624570
- 208
- Rosenberg SI. Vestibular surgery for Ménière’s disease in the elderly: a review of techniques and indications. Ear Nose Throat J 1999;78:443-6. PMID 10388195
- 209
- Ruckenstein MJ. Immunologic aspects of Meniere’s disease. Am J Otolaryngol 1999;20:161-5. PMID 10326751
- 210
- Russo FY, Nguyen Y, De Seta D, et al. Meniett device in Meniere disease: randomized, double-blind, placebo-controlled multicenter trial. Laryngoscope 2017;127(2):470-5. PMID 27515294
- 211
- Saberi A, Nemati S, Amlashi TT, Tohidi S, Bakhshi F. Phonophobia and migraine features in patients with definite Meniere's disease: Pentad or triad/tetrad? Acta Otolaryngol 2020;140(7):548-52. PMID 32281461
- 212
- Sajjadi H, Paparella MM. Meniere’s disease. Lancet 2008;372(9636):406-14. PMID 18675691
- 213
- Santosh UP, Rao MS. Incidence of hypothyroidism in Meniere's disease. J Clin Diagn Res 2016;10(5):MC01-3. PMID 27437251
- 214
- Scarpa A, Avallone E, Carucci M, et al. Efficacy and preservation of hearing with low-dose gentamicin in unilateral meniere's disease: a clinical symptomatology-based study. Am J Otolaryngol 2024;45(1):104116. PMID 37984050
- 215
- Schuknecht HF. Ablation therapy in the management of Meniere’s disease. Acta Otolaryngol Suppl 1957;132:1-42. PMID 13457879
- 216
- Schuknecht HF. Meniere’s disease: a correlation of symptomatology and pathology. Laryngoscope 1963;73:651-5. PMID 13987152
- 217
- Schuknecht HF. The pathophysiology of Meniere’s disease. Am J Otol 1984;5:526-7. PMID 6393773
- 218
- Schuknecht HF, Igarashi M. Pathophysiology of Meniere’s disease. In: Pfaltz CR, editor. Controversial aspects of Meniere’s disease. New York: Georg Thieme, Inc, 1986:46-54.
- 219
- Selleck AM, Dillon M, Perkins E, Brown KD. Cochlear implantation in the setting of Menière's disease after labyrinthectomy: a meta-analysis. Otol Neurotol 2021;42(8):e973-9. PMID 34049331
- 220
- Sepahdari AR, Vorasubin N, Ishiyama G, Ishiyama A. Endolymphatic hydrops reversal following acetazolamide therapy: demonstration with delayed intravenous contrast-enhanced 3D-FLAIR MRI. AJNR Am J Neuroradiol 2016;37(1):151-4. PMID 26381561
- 221
- Seyed Tootoonchi SJ, Ghiasi S, Shadara P, Samani SM, Fouladi DF. Hearing function after betahistine therapy in patients with Ménière's disease. Braz J Otorhinolaryngol 2016;82(5):500-6. PMID 26810620
- 222
- Shapiro SL. Ménière’s autopsy report. Eye Ear Nose Throat Mon 1970;49(4):199-202. PMID 4921301
- 223
- Shea JJ Jr, Ge X, Orchik DJ. Traumatic endolymphatic hydrops. Am J Otol 1995;16(2):235-40. PMID 8572126
- 224
- Shen LL, Andresen NS, Chari DA, et al. Otolith membrane herniation, not semicircular canal duct dilation, is associated with decreased caloric responses in Ménière's disease. J Assoc Res Otolaryngol 2023;24(1):95-106. PMID 36539657
- 225
- Shim T, Strum DP, Mudry A, Monfared A. Hold the salt: history of salt restriction as a first-line therapy for Menière's disease. Otol Neurotol 2020;41(6):855-9. PMID 32221112
- 226
- Shupak A, Faranesh N. Bone mineral density in patients suffering from Ménière's disease. Audiol Neurootol 2020;25(3):158-63. PMID 32088708
- 227
- Silverstein H, Smouha E, Jones R. Natural history vs. surgery for Meniere’s disease. Otolaryngol Head Neck Surg 1989;100:6-16. PMID 2493618
- 228
- Simon F, Guichard JP, Kania R, Franc J, Herman P, Hautefort C. Saccular measurements in routine MRI can predict hydrops in Menière's disease. Eur Arch Otorhinolaryngol 2017;274(12):4113-20. PMID 28951962
- 229
- Skarp S, Korvala J, Kotimäki J, Sorri M, Männikkö M, Hietikko E. New genetic variants in CYP2B6 and SLC6A support the role of oxidative stress in familial Ménière's disease. Genes (Basel) 2022;13(6):998. PMID 35731759
- 230
- Soderman AH, Möller J, Bagger-Sjöbäck D, Bergenius J, Hallqvist J. Stress as a trigger of attacks in Menière’s disease. A case-crossover study. Laryngoscope 2004;114(10):1843-8. PMID 15454783
- 231
- Smith WK, Sankar V, Pfleiderer AG. A national survey amongst UK otolaryngologists regarding the treatment of Meniere’s disease. J Laryngol Otol 2005;119:102-5. PMID 15829061
- 232
- Stahle J, Wilbrand HF. The temporal bone in patients with Meniere's disease. Acta Otolaryngol 1983;95(1-2):81-94. PMID 6829306
- 233
- Sun W, Guo P, Ren T, Wang W. Magnetic resonance imaging of intratympanic gadolinium helps differentiate vestibular migraine from Ménière disease. Laryngoscope 2017;127(10):2382-8. PMID 28220492
- 234
- Sun Z, Zhang Y, Liu B, Duan J, Liu G, Zhou X. The correlation of hearing prognosis and caloric test results in Meniere's disease: a follow-up study. Acta Otolaryngol 2024;144(2):100-6. PMID 38436675
- 235
- Sykopetrites V, Giannuzzi AL, Lauda L, Di Rubbo V, Bassi M, Sanna M. Surgical labyrinthectomy and cochlear implantation in Menière's disease. Otol Neurotol 2020;41(6):775-81. PMID 32282785
- 236
- Talewar KK, Cassidy E, McIntyre A. Living with Ménière's disease: an interpretative phenomenological analysis. Disabil Rehabil 2020;42(12):1714-26. PMID 30668168
- 237
- Tamanini JB, Mezzalira R, Vallim MG, Gabriel GP, Stoler G, Chone CT. Dissociation between video head impulse test and caloric test: a marker of Menière's disease? A systematic review and meta-analysis. Braz J Otorhinolaryngol 2023;89(4):101279. PMID 37354884
- 238
- Taniguchi AN, Sutton SR, Mills JF, et al. Placebo effect in randomized controlled trials for Meniere's disease: a meta-analysis. Am J Otolaryngol 2024;45(2):104178. PMID 38101129
- 239
- Tawk K, Kim JK, Frank M, Goshtasbi K, Abouzari M, Djalilian HR. Correlation between laterality of hearing loss and migraine features in Menière's disease. Otol Neurotol 2023;44(7):651-5. PMID 37317519
- 240
- Thomsen J, Bonding P, Becker B, Stage J, Tos M. The non-specific effect of endolymphatic sac surgery in treatment of Meniere’s disease: a prospective, randomized controlled study comparing “classic” endolymphatic sac surgery with the insertion of a ventilating tube in the tympanic membrane. Acta Otolaryngol 1998;118:769-73. PMID 9870617
- 241
- Thomsen J, Vesterhauge S. A critical evaluation of the glycerol test in Meniere’s disease. Adv Otorhinolaryngol 1979;25:49-53. PMID 484357
- 242
- Timmer FC, Zhou G, Guinan JJ, Kujawa SG, Herrmann BS, Rauch SD. Vestibular evoked myogenic potential (VEMP) in patients with Meniere's disease with drop attacks. Laryngoscope 2006;116(5):776-9. PMID 16652086
- 243
- Tonndorf J. Mechanical causes of fluctuant hearing loss. Otolaryngol Clin North Am 1975;8:303-13. PMID 1153199
- 244
- Tunon Gomez M, Lobo Duro DR, Brea Álvarez B, García-Berrocal JR. Diagnosis of endolymphatic hydrops by means of 3T magnetic resonance imaging after intratympanic administration of gadolinium. Radiologia 2017;59(2):159-65. PMID 28017456
- 245
- van Deelen GW, Huizing EH. Use of a diuretic (Dyazide) in the treatment of Meniere’s disease. A double-blind cross-over placebo-controlled study. ORL J Otorhinolaryngol Relat Spec 1986;48:287-92. PMID 3537899
- 246
- van der Lubbe MFJA, Vaidyanathan A, Van Rompaey V, et al. The "hype" of hydrops in classifying vestibular disorders: a narrative review. J Neurol 2020;267(Suppl 1):197-211. PMID 33201310
- 247
- van Esch B, van der Zaag-Loonen H, Bruintjes T, van Benthem PP. Betahistine in Ménière's disease or syndrome: a systematic review. Audiol Neurootol 2022a;27(1):1-33. PMID 34233329
- 248
- van Esch BF, van der Zaag-Loonen H, Bruintjes T, Kuijpers T, van Benthem PPG. Interventions for Menière's disease: an umbrella systematic review. BMJ Evid Based Med 2022b;27(4):235-45.** PMID 34750154
- 249
- van Steekelenburg JM, van Weijnen A, de Pont LM, et al. Value of endolymphatic hydrops and perilymph signal intensity in suspected Ménière disease. AJNR Am J Neuroradiol 2020;41(3):529-34. PMID 32029469
- 250
- van Tilburg MJ, Herrmann BS, Guinan JJ Jr, Rauch SD. Serial cVEMP testing is sensitive to disease progression in Ménière patients. Otol Neurotol 2016;37(10):1614-9. PMID 27668791
- 251
- Viana LM, Bahmad F Jr, Rauch SD. Intratympanic gentamicin as a treatment for drop attacks in patients with Meniere's disease. Laryngoscope 2014;124(9):2151-4. PMID 24729095
- 252
- Vibert D, Caversaccio M, Häusler R. Meniere's disease in the elderly. Otolaryngol Clin North Am 2010;43(5):1041-6. PMID 20713243
- 253
- Villavisanis DF, Mavrommatis MA, Berson ER, et al. Cochlear implantation in Meniere's disease: a systematic review and meta-analysis. Laryngoscope 2021;131(8):1845-54. PMID 33464598
- 254
- Webster KE, George B, Lee A, et al. Lifestyle and dietary interventions for Ménière's disease. Cochrane Database Syst Rev 2023a;2(2):CD015244.** PMID 36848645
- 255
- Webster KE, Lee A, Galbraith K, et al. Intratympanic corticosteroids for Ménière's disease. Cochrane Database Syst Rev 2023b;2(2):CD015245.** PMID 36847608
- 256
- Webster KE, Galbraith K, Lee A, et al. Intratympanic gentamicin for Ménière's disease. Cochrane Database Syst Rev 2023c;2(2):CD015246.** PMID 36847592
- 257
- Webster KE, Galbraith K, Harrington-Benton NA, et al. Systemic pharmacological interventions for Ménière's disease. Cochrane Database Syst Rev 2023d;2(2):CD015171.** PMID 36827524
- 258
- Webster KE, George B, Galbraith K, et al. Positive pressure therapy for Ménière's disease. Cochrane Database Syst Rev 2023e;2(2):CD015248.** PMID 36815713
- 259
- Wen MH, Cheng PW, Young YH. Augmentation of ocular vestibular-evoked myogenic potentials via bone-conducted vibration stimuli in Ménière disease. Otolaryngol Head Neck Surg 2012;146(5):797-803. PMID 22237297
- 260
- Wetmore SJ. Endolymphatic sac surgery for Ménière’s disease: long-term results after primary and revision surgery. Arch Otolaryngol Head Neck Surg 2008;134(11):1144-8. PMID 19015441
- 261
- Williams HL. A review of Ménière’s original papers in the light of our present knowledge of Ménière’s disease. Ann Otol Rhinol Laryngol 1949;58:761-70. PMID 15397202
- 262
- Wu PL, Lin HC, Chien WC, Chung CH, Chen JW. Increased risk of injury in Ménière's disease and effects of treatment: population-based retrospective cohort study. Otolaryngol Head Neck Surg 2023a;168(3):443-52. PMID 35763347
- 263
- Wu Q, Dai C, Zhao M, Sha Y. The correlation between symptoms of definite Meniere's disease and endolymphatic hydrops visualized by magnetic resonance imaging. Laryngoscope 2016;126(4):974-9. PMID 26333096
- 264
- Wu V, Sykes EA, Beyea MM, Simpson MTW, Beyea JA. Approach to Ménière disease management. Can Fam Physician 2019;65(7):463-7. PMID 31300426
- 265
- Wu Y, Ling X, Song N, et al. Comparison of clinical characteristics and vestibular function test results in patients with vestibular migraine and Menière's disease. Braz J Otorhinolaryngol 2023b;89(4):101274. PMID 37331235