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Opsoclonus-myoclonus

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Opsoclonus-myoclonus

The patient is a 2.5-year-old girl who developed opsoclonus, myoclonus, and ataxia after an illness characterized by high fever and ulcerations of oral mucosa. She was treated with adrenocorticotrophic hormone (ACTH) for five days but then relapsed after treatment was stopped. After four months, at the time of this video, she had been started on a second course of ACTH, with immediate resolution of opsoclonus and myoclonus but slow resolution of ataxia, irritability, and lost language milestones. (Contributed by Dr. David A Griesemer.)

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Associated Disorders

  • Acute cerebellar encephalopathy
  • Infantile myoclonic encephalopathy
  • Myoclonic encephalopathy
  • Neural crest tumor
  • Neuroblastoma