Infantile neuroaxonal dystrophy
Aug. 13, 2021
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Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
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This man with advanced Parkinson disease has characteristic extrapyramidal signs during the true “off” state (at least 12 hours after last dose of levodopa). The signs include a coarse tremor, which involves the left lower extremity preponderantly--an unusual finding, rigidity, bradykinesia, masked face, hypophonia, and loss of associated movements. With deep brain stimulation (DBS) of the right subthalamic nucleus (STN), he gets relief of the left lower limb tremor and some other extrapyramidal signs but develops left-sided hemiballism, worse in the upper limb, and worse dysarthria. (Contributed by Dr. Joseph Jankovic.)