Primary systemic amyloidosis: neurologic complications
Amyloidosis refers to the extracellular deposition of fibrils composed of low weight chain of a variety of normal serum proteins. The autosomal dominant hereditary transthyretin amyloidosis (hATTR) and the acquired light chain (AL)-amyloidosis, the result of a plasma cell dyscrasia, are the 2 most common types of amyloidosis associated with peripheral neuropathy. In both, the main presentation is a painful, length-dependent small fiber neuropathy starting in the feet, with numbness, burning and allodynia, which can be particularly worse at night.
Feb. 12, 2020