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Yalow successfully developed radioimmunoassays for peptide hormones, including parathyroid hormone. (Courtesy of Wikipedia. Public domain.)
Aug. 26, 2021
Amyloid myopathy is one of the uncommon manifestations of systemic amyloidosis. The symptoms are usually nonspecific, typically including progressive proximal limb weakness with an increased creatine kinase level, macroglossia, and muscle pseudohypertrophy. It is often misdiagnosed as inflammatory myopathy, even when a muscle biopsy is available. When suspecting amyloid myopathy, Congo red staining and either an immunohistochemical assay or immunofluorescence study should be performed.
Oct. 16, 2020
Clinical trials should fulfill standard criteria for methodological quality, assuring an objective estimate of treatment effects. The quality of clinical trials is now frequently evaluated according to the CONSORT statement. Currently, there are 14 FDA-approved disease-modifying therapies available for the treatment of relapsing-remitting multiple sclerosis.
Mar. 16, 2020
Childhood Degenerative & Metabolic Disorders
Sep. 06, 2020
Hiccups are inappropriate respiratory muscle contractions that can occur due to gastrointestinal, respiratory, neurologic, or systemic disorders, brainstem lesions, benign posterior fossa tumors, surgery, or adverse reaction to drugs. Management is mostly medical using pharmacologic agents.
Jul. 11, 2021
Headache & Pain
Headaches are often part of the acute mononucleosis-like illness experienced as part of the primary infection with HIV-1. Headaches in these individuals range from a febrile headache associated with the systemic viral infection to headaches associated with retro-orbital pain, photophobia, and meningeal signs, reflecting acute viral lymphocytic meningitis. Headaches may also be secondary to an opportunistic infection or tumor or may be due to medication.
Feb. 24, 2021
Insomnia appears in several forms: (1) difficulty initiating sleep, (2) repeated or lengthy awakenings, (3) early awakenings, (4) inadequate total sleep time, or (5) poor quality of sleep as reflected by its consequences, including daytime sleepiness. The ICSD-3 defines 3 different classification systems for insomnia: chronic insomnia disorder, short-term insomnia disorder, and other insomnia disorder. Complications of insomnia include impaired responses to infections, increase in inflammation, higher levels of the stress hormone cortisol, and other biomarkers related to fatigue and poor health.
Oct. 11, 2020
Feb. 20, 2021