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GAD active site with Schiff base linkage between PLP and Lys405

GAD67 active site containing PLP-glutamate complex (shown in green), with Schiff base linkage at Lys405. Side chain residues shown in red. (Source: Image by "OceanicTrees" via Wikipedia. Creative Commons Attribution-Share Alike 4.0 International License,

Associated Disorders

  • Vitamin deficiency and toxicity