Dec. 06, 2021
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In the classic model of basal ganglia function, the subthalamic nucleus provides excitatory glutamatergic drive to the GPi. Increased activity in the GPi inhibits the motor thalamus, with a resulting decrease in cortical activation and inhibition of movement. Reduced activity from the GPi would have the opposite effect, thus, disinhibiting the thalamus. (Contributed by Dr. Rita Tranquilli.)