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Pantothenate kinase-associated neurodegeneration

Axial T2-weighted MRI images showing the characteristic MRI features of symmetrical hypointense globus pallidi with small central area of hyperintensity, referred to as the “eye of the tiger” sign seen in (A) an 8-year-old girl with pantothenate kinase-associated neurodegeneration and (B) a 55-year-old woman with late-onset pantothenate kinase-associated neurodegeneration. (Contributed by Dr. Brian Berman.)

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  • Choreiform movement disorders
  • Dystonia
  • Essential tremor
  • Huntington disease
  • Multiple system atrophy
  • Parkinson disease
  • Paroxysmal dystonic choreoathetosis
  • Progressive supranuclear palsy
  • Tourette syndrome