Stroke & Vascular Disorders
Primary prevention of stroke
Dec. 28, 2023
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Alternate (acidic) pathway of bile acid biosynthesis
Selected enzymes are shown in red boxes. The red arrows show the abnormal synthetic step in cerebrotendinous xanthomatosis, due to deficiency or dysfunction of the enzyme cytochrome P450 27A1 (CYP27A1). This is the rate-limiting enzyme that initiates the alternate pathway. (Illustration by Dr. Douglas J Lanska.)
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Associated
Disorders
- Ataxia
- Behavioral problems
- Bone fractures
- Bulbar palsy
- Cerebellar syndrome
- Chronic diarrhea in children
- Degenerative CNS disease
- Dementia
- Epileptic seizures
- Gallstones
- Ischemic heart disease
- Juvenile cataracts
- Kidney stones
- Leukoencephalopathy
- Marinesco-Sjogren syndrome
- Mental retardation
- Mitochondrial myopathy
- Myelopathy
- Myopathic-like faces
- Nephrocalcinosis
- Nephrolithiasis
- Neurometabolic disease
- Osteoporosis
- Paraparesis
- Paraplegia
- Parkinsonism
- Peripheral polyneuropathy
- Pes cavus
- Pontocerebellar degeneration
- Psychiatric disorders
- Xanthomata