Lewy body dementia: Lewy bodies and Lewy neurites in neocortex on autopsy

At autopsy of elderly patient with Lewy body dementia, there was a high burden of alpha-synculein-positive Lewy bodies and Lewy neurites in the neocortex, consistent with a primary neuropathological diagnosis of Lewy body disease or dementia with Lewy bodies along with high levels of Alzheimer disease-associated tau tangles and amyloid plaques consistent with a secondary diagnosis of Alzheimer disease. (Contributed by Dr. David J Irwin.)