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Thiamin pyrophosphate (TPP)

Thiamin pyrophosphate (TPP), the coenzyme of E1k, catalyzes the reversible decarboxylation of alpha-ketoglutarate. (Courtesy of Wikimedia Commons. Public domain.)

Associated Disorders

  • DOOR syndrome
  • Dihydrolipoyl dehydrogenase deficiency
  • Eronen syndrome
  • Ketoacidotic crisis
  • Lactic acidosis
  • Maple syrup urine disease